The State Key Laboratory of Pharmaceutical Biotechnology, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China.
Cells. 2021 Aug 25;10(9):2195. doi: 10.3390/cells10092195.
Mitochondria associated membranes (MAM), which are the contact sites between endoplasmic reticulum (ER) and mitochondria, have emerged as an important hub for signaling molecules to integrate the cellular and organelle homeostasis, thus facilitating the adaptation of energy metabolism to nutrient status. This review explores the dynamic structural and functional features of the MAM and summarizes the various abnormalities leading to the impaired insulin sensitivity and metabolic diseases.
线粒体相关膜（MAM）是内质网（ER）和线粒体之间的接触位点，它已经成为信号分子整合细胞和细胞器稳态的重要枢纽，从而促进能量代谢适应营养状态。本文探讨了 MAM 的动态结构和功能特征，并总结了导致胰岛素敏感性受损和代谢性疾病的各种异常。
