Research Institute of Neuromuscular and Neurodegenerative Disease, Department of Neurology, Qilu Hospital, Shandong University, Jinan, China; Neurology Department, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 DaHua Road, Dong Dan, Beijing, 100730, PR China.
Neurology Department, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 DaHua Road, Dong Dan, Beijing, 100730, PR China.
Clin Neurol Neurosurg. 2021 Mar;202:106523. doi: 10.1016/j.clineuro.2021.106523. Epub 2021 Jan 29.
To understand the distribution of Parkinson's disease questionnaire-39 (PDQ-39) scores in Parkinson's disease (PD) patients with or without depression, and to analyze the factors that influence the quality of life of PD patients.
300 PD patients were enrolled. Patients' general information and the results of assessments including UPDRS, H-Y, HAMD, HAMA, ADL and PDQ-39 were collected. They were divided into depression group and non-depression group according to HAMD score. The relationship between PD-related depression and quality of life and the factors that influence the quality of life of PD patients were analyzed based on PDQ-39 score.
111 patients with depression (37.0 %) and 189 patients without depression (63.0 %) were enrolled. The scores of PDQ-39 summary index (PDQ-39 SI) in the depression group were significantly higher than those in the non-depression group in all domains (P < 0.05). Patients in the depression group had a longer disease duration (6.89 ± 4.70 vs. 5.52 ± 4.12, P < 0.038), a higher UPDRS-III score (30.1 ± 13.55 vs. 25.2 ± 11.73, P < 0.001), and a higher H-Y stage level (2.41 ± 0.853 vs. 2.13 ± 0.707, P < 0.001), compared with patients in the non-depression group. All factors including age, disease duration, UPDRS-III, H-Y stage, HAMD score and HAMA score, may independently affected PDQ-39SI in PD patients, among which HAMD had the greatest effect. HAMD and HAMA were correlated with PDQ-39 in its all eight domains.
PD patients with psychological problems such as anxiety and depression may lead to a significant decline in the quality of life of patients in all domains.
了解伴或不伴抑郁的帕金森病（PD）患者帕金森病问卷 39 项（PDQ-39）评分的分布情况，并分析影响 PD 患者生活质量的因素。
纳入 300 例 PD 患者，收集患者的一般资料及 UPDRS、H-Y、HAMD、HAMA、ADL 及 PDQ-39 等评估结果。根据 HAMD 评分将患者分为抑郁组和非抑郁组，分析 PD 相关抑郁与生活质量的关系及 PDQ-39 评分与 PD 患者生活质量的影响因素。
共纳入抑郁患者 111 例（37.0%）和非抑郁患者 189 例（63.0%）。抑郁组 PDQ-39 综合指数（PDQ-39 SI）各领域评分均明显高于非抑郁组（P<0.05）。抑郁组患者病程较长[（6.89±4.70）比（5.52±4.12），P<0.038]、UPDRS-III 评分较高[（30.1±13.55）比（25.2±11.73），P<0.001]、H-Y 分期较高[（2.41±0.853）比（2.13±0.707），P<0.001]。年龄、病程、UPDRS-III、H-Y 分期、HAMD 评分、HAMA 评分均可能独立影响 PD 患者 PDQ-39SI，其中 HAMD 评分影响最大。HAMD 和 HAMA 与 PDQ-39 的 8 个领域均相关。
伴焦虑和抑郁等心理问题的 PD 患者可能导致患者各领域生活质量显著下降。
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