Gay C T, Marks W A, Riley H D, Bodensteiner J B, Hamza M, Noorani P A, Bobele G B
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City.
South Med J. 1988 Apr;81(4):457-60. doi: 10.1097/00007611-198804000-00012.
We present the first two known cases of infantile botulism in Oklahoma. The first case was due to type B toxin; the second was due to type A toxin. Both cases demonstrate most of the classic features of what now appears to be the most common form of botulism. Infantile botulism is an underrecognized but reversible cause of hypotonia. In most cases, the prognosis is excellent with institution of appropriate supportive care. The recognition of cranial nerve palsies or a history of constipation should raise the suspicion of infantile botulism. Aminoglycoside antibiotics and other agents that may precipitate or exacerbate neuromuscular blockade should be used with extreme caution in hypotonic infants until the cause of the hypotonia is clearly identified.
我们报告了俄克拉何马州已知的首例两例婴儿肉毒中毒病例。第一例由B型毒素引起；第二例由A型毒素引起。两例病例均表现出了现在看来是肉毒中毒最常见形式的大多数典型特征。婴儿肉毒中毒是一种未得到充分认识但可逆转的肌张力减退病因。在大多数情况下，通过给予适当的支持性治疗，预后良好。认识到颅神经麻痹或便秘史应引起对婴儿肉毒中毒的怀疑。在明确肌张力减退的病因之前，对于肌张力减退的婴儿，应极其谨慎地使用氨基糖苷类抗生素和其他可能引发或加重神经肌肉阻滞的药物。
