Liu Yang, Yang Xiaohe, Wang Yali, Yang Yueying, Sun Dejuan, Li Hua, Chen Lixia
Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Eur J Med Chem. 2021 Mar 15;214:113264. doi: 10.1016/j.ejmech.2021.113264. Epub 2021 Feb 6.
With the change of lifestyle and the acceleration of aging process, inflammatory diseases have increasingly become one of the most vital threats to global human health. SHP2 protein is a non-receptor tyrosine phosphatase encoded by PTPN11 gene, and it is widely expressed in various tissues and cells. Numerous studies have shown that SHP2 plays important roles in the regulation of inflammatory diseases, including cancer-related inflammation, neurodegenerative diseases and metabolic diseases. In this paper, the roles of SHP2 in inflammatory diseases of various physiological systems were reviewed. At the same time, the latest SHP2 inhibitors were summarized, which will hold a promise for the therapeutic potential in future.
随着生活方式的改变和衰老进程的加速，炎症性疾病日益成为全球人类健康面临的最重要威胁之一。SHP2蛋白是一种由PTPN11基因编码的非受体酪氨酸磷酸酶，在各种组织和细胞中广泛表达。大量研究表明，SHP2在炎症性疾病的调控中发挥着重要作用，包括癌症相关炎症、神经退行性疾病和代谢性疾病。本文综述了SHP2在各种生理系统炎症性疾病中的作用。同时，总结了最新的SHP2抑制剂，这将为未来的治疗潜力带来希望。
