Neurodegeneration and Neuroregeneration Laboratory, Department of Basic Medicine, School of Medicine, Shaoxing University, Shaoxing 312000, Zhejiang, China.
Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China.
Biomed Pharmacother. 2021 May;137:111360. doi: 10.1016/j.biopha.2021.111360. Epub 2021 Feb 11.
By virtue of their small size, nanomaterials can cross the blood-brain barrier and, when modified to target specific cells or regions, can achieve high bioavailability at the intended site of action. Modified nanomaterials are therefore promising agents for the diagnosis and treatment of neurodegenerative diseases such as Alzheimer's disease (AD). Here we review the roles and mechanisms of action of nanomaterials in AD. First, we discuss the general characteristics of nanomaterials and their application to nanomedicine. Then, we summarize recent studies on the diagnosis and treatment of AD using modified nanomaterials. These studies indicate that using nanomaterials is a potential strategy for AD treatment by slowing the progression of AD through enhanced therapeutic effects.
由于其体积小，纳米材料可以穿透血脑屏障，并且经过修饰以靶向特定细胞或区域后，可在预期的作用部位实现高生物利用度。因此，经过修饰的纳米材料是治疗神经退行性疾病（如阿尔茨海默病（AD））的有前途的药物。在这里，我们综述了纳米材料在 AD 中的作用和作用机制。首先，我们讨论了纳米材料的一般特性及其在纳米医学中的应用。然后，我们总结了最近使用修饰后的纳米材料进行 AD 诊断和治疗的研究。这些研究表明，通过增强治疗效果来减缓 AD 的进展，使用纳米材料是治疗 AD 的一种潜在策略。
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