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SARS-CoV-2 感染后妊娠期间抗体反应的纵向分析：从孕早期到分娩。

Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery.

机构信息

Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.

Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.

出版信息

J Reprod Immunol. 2021 Apr;144:103285. doi: 10.1016/j.jri.2021.103285. Epub 2021 Feb 2.

DOI:10.1016/j.jri.2021.103285
PMID:33582489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7973007/
Abstract

We report herein the longest-lasting study of SARS-CoV-2 antibody profile in pregnancy, from first trimester-infection to delivery. Seventeen out of 164 pregnant women tested positive for COVID-19. Throughout pregnancy, the neutralizing antibody titer remained stable, whilst a significant decline in the non-neutralizing antibodies was observed after 16 weeks of gestation. All the newborns of women who developed IgG antibodies showed the presence of the same antibodies in arterial cord blood. Knowledge on the longevity and type of SARS-CoV-2 antibody response may help to guide vaccination strategies in pregnancy.

摘要

我们在此报告 SARS-CoV-2 抗体谱在妊娠中的最长时间研究，从妊娠早期感染到分娩。164 名孕妇中有 17 名新冠病毒检测呈阳性。在整个妊娠期间，中和抗体滴度保持稳定，而在妊娠 16 周后，非中和抗体显著下降。所有母亲 IgG 抗体阳性的新生儿的脐动脉血中都存在相同的抗体。对 SARS-CoV-2 抗体反应的持续时间和类型的了解可能有助于指导妊娠中的疫苗接种策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b382/7973007/906f7141ce74/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b382/7973007/906f7141ce74/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b382/7973007/906f7141ce74/gr1_lrg.jpg

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本文引用的文献

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JAMA Netw Open. 2020 Dec 1;3(12):e2030455. doi: 10.1001/jamanetworkopen.2020.30455.
2
Antibody Responses 8 Months after Asymptomatic or Mild SARS-CoV-2 Infection.无症状或轻症 SARS-CoV-2 感染 8 个月后的抗体反应。
Emerg Infect Dis. 2021 Mar;27(3):928-931. doi: 10.3201/eid2703.204543. Epub 2020 Dec 22.
3
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
COVID-19 对母婴生命体征的影响：一项系统综述。
J Pregnancy. 2023 May 13;2023:3015072. doi: 10.1155/2023/3015072. eCollection 2023.
4
Maternal Antibody Response and Transplacental Transfer Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection or Vaccination in Pregnancy.母体抗体反应和胎盘转移在妊娠期间严重急性呼吸综合征冠状病毒 2 感染或接种疫苗后。
Clin Infect Dis. 2023 Jan 13;76(2):220-228. doi: 10.1093/cid/ciac793.
5
Clinical, Laboratory, and Imaging Findings of Pregnant Women with Possible Vertical Transmission of SARS-CoV-2-Case Series.孕妇可能垂直传播 SARS-CoV-2 的临床、实验室和影像学表现——病例系列。
Int J Environ Res Public Health. 2022 Sep 1;19(17):10916. doi: 10.3390/ijerph191710916.
6
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Am J Reprod Immunol. 2022 Jul;88(1):e13550. doi: 10.1111/aji.13550. Epub 2022 May 9.
7
Maternal-Fetal Implications of SARS CoV-2 Infection during Pregnancy, Viral, Serological Analyses of Placenta and Cord Blood.妊娠合并 SARS-CoV-2 感染的母婴影响，胎盘和脐血的病毒、血清学分析。
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8
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J Obstet Gynaecol Res. 2022 Feb;48(2):393-401. doi: 10.1111/jog.15105. Epub 2021 Nov 23.
9
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10
Persistence of infection-induced SARS-CoV-2 seropositivity throughout gestation.妊娠期间感染诱导的新冠病毒血清阳性持续存在。
Am J Obstet Gynecol. 2022 Feb;226(2):263-264. doi: 10.1016/j.ajog.2021.09.037. Epub 2021 Oct 2.
BNT162b2 mRNA 新冠病毒疫苗的安全性和有效性。
N Engl J Med. 2020 Dec 31;383(27):2603-2615. doi: 10.1056/NEJMoa2034577. Epub 2020 Dec 10.
4
Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans.人类感染 SARS-CoV-2 后三个月内中和抗体反应的纵向观察和下降。
Nat Microbiol. 2020 Dec;5(12):1598-1607. doi: 10.1038/s41564-020-00813-8. Epub 2020 Oct 26.
5
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6
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.无症状或轻症 COVID-19 康复者体内具有强大的 T 细胞免疫。
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7
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9
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10
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Eur J Obstet Gynecol Reprod Biol. 2019 Sep;240:375-376. doi: 10.1016/j.ejogrb.2019.04.022. Epub 2019 Apr 19.