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[暴露于塔夫辛的大鼠视觉和感觉运动皮层神经元形态化学变化的比较分析]

[Comparative analysis of the morphochemical changes in the visual and sensorimotor cortical neurons of rats exposed to taftsin].

作者信息

Chebotareva T L

出版信息

Tsitologiia. 1988 Jan;30(1):76-80.

PMID:3358283
Abstract

White rats were treated with a single administration of immunostimulator tuftsin (Thr-Lys-Pro-Arg, in the dose 300 mcg/kg b. w.). By interferometry protein content and concentration and the area of neuron cytoplasm and nucleus were assessed 15 minutes after injection, significant alterations in protein content and cellular area were detected in one type neurons of visual and sensomotor cortex. A possible interrelation is discussed between tuftsin action and the functional activity of neurons, and between the level of their protein metabolism and establishment of emotional and motor response.

摘要

给白鼠单次注射免疫刺激剂缩氨酸(苏氨酸-赖氨酸-脯氨酸-精氨酸,剂量为300微克/千克体重)。通过干涉测量法,在注射后15分钟评估蛋白质含量、浓度以及神经元细胞质和细胞核的面积,在视觉和感觉运动皮层的一类神经元中检测到蛋白质含量和细胞面积有显著变化。讨论了缩氨酸作用与神经元功能活动之间以及它们的蛋白质代谢水平与情绪和运动反应建立之间可能的相互关系。

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