Sang Yu, Mao Kai-Min, Huang Yi, Wu Xiao-Fen, Wang Xing-Fen, Ruan Lei, Zhang Cun-Tai
Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Department of Pulmonary and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Curr Med Sci. 2021 Feb;41(1):94-99. doi: 10.1007/s11596-021-2324-3. Epub 2021 Feb 13.
Fibulin-1 (FBLN-1), an elastin-associated extracellular matrix protein, has been found in blood and may play a role in the pathophysiological processes leading to cardiovascular disease (CVD). We aimed to investigate the relationship between fibulin-1 levels and the risk of CVD by evaluating vascular age derived from the Framingham Heart Study and brachial-ankle Pulse Wave Velocity (baPWV) in patients with asymptomatic hyperuricemia (AHU). In total, 66 patients with AHU and 66 gender- and age-matched healthy individuals were enrolled. The plasma fibulin-1 levels were measured by immunochemistry. Patients with AHU presented significantly higher vascular age [median (interquartile range): 54 (22) vs. 48 (14) years, P=0.01] and baPWV [mean±SD: 1373±223 vs. 1291±177 cm/s, P=0.02] than the healthy subjects; however, no significant difference was observed in the plasma fibulin-1 level between the patients with AHU and healthy subjects [median (interquartile range): 4018 (3838) vs. 3099 (3405) ng/mL, P=0.31]. A correlation between fibulin-1 levels and baPWV was observed only in patients with AHU (r=0.29, P=0.02); and there was also a suggestively statistically significant correlation between fibulin-1 levels and vascular age (r=0.22, P=0.08). However, these associations were rendered insignificant after adjustments for potential confounders. In healthy subjects, no correlation was observed between fibulin-1 levels and CVD risk. This study reveals that plasma fibulin-1 levels may reflect the CVD risk in patients with AHU, but the relationship is not robust.
纤连蛋白-1（FBLN-1）是一种与弹性蛋白相关的细胞外基质蛋白，已在血液中被发现，可能在导致心血管疾病（CVD）的病理生理过程中发挥作用。我们旨在通过评估来自弗雷明汉心脏研究的血管年龄以及无症状高尿酸血症（AHU）患者的臂踝脉搏波速度（baPWV），来研究纤连蛋白-1水平与CVD风险之间的关系。总共纳入了66例AHU患者和66例性别及年龄匹配的健康个体。通过免疫化学方法测定血浆纤连蛋白-1水平。AHU患者的血管年龄[中位数（四分位间距）：54（22）岁对48（14）岁，P = 0.01]和baPWV[均值±标准差：1373±223对1291±177 cm/s，P = 0.02]显著高于健康受试者；然而，AHU患者与健康受试者之间的血浆纤连蛋白-1水平无显著差异[中位数（四分位间距）：4018（3838）对3099（3405）ng/mL，P = 0.31]。仅在AHU患者中观察到纤连蛋白-1水平与baPWV之间存在相关性（r = 0.29，P = 0.02）；纤连蛋白-1水平与血管年龄之间也存在提示性的统计学显著相关性（r = 0.22，P = 0.08）。然而，在对潜在混杂因素进行调整后，这些关联变得不显著。在健康受试者中，未观察到纤连蛋白-1水平与CVD风险之间存在相关性。这项研究表明，血浆纤连蛋白-1水平可能反映AHU患者的CVD风险，但这种关系并不稳固。
