Pastushkova Ludmila Kh, Rusanov Vasily B, Goncharova Anna G, Nosovskiy Andrei M, Luchitskaya Elena S, Kashirina Daria N, Kononikhin Alexey S, Kussmaul Anna R, Yakhya Yusef D, Larina Irina M, Nikolaev Evgeny N
Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia.
Skolkovo Institute of Science and Technology, Skolkovo, Russia.
Front Physiol. 2021 Nov 17;12:760875. doi: 10.3389/fphys.2021.760875. eCollection 2021.
The study presents the results of evaluating the changes in the concentrations of blood plasma proteins associated with heart rate variability (HRV) in cosmonauts who have completed space missions lasting about 6months. The concentrations of 125 proteins were quantified in biological samples of the cosmonauts' blood plasma. The subgroups of proteins associated with the physiological processes of the HRV autonomic regulation were identified using bioinformatic resources (Immunoglobulin heavy constant mu, Complement C1q subcomponent subunit C, Plasma serine protease inhibitor, Protein-72kDa type IV collagenase, Fibulin-1, Immunoglobulin lambda constant 3). The concentration of these proteins in the blood plasma before the flight, and the dynamics of concentration changes on the 1st and 7th days of the post-flight rehabilitation period differed in the groups of cosmonauts with a predominance of sympathetic or parasympathetic modulating autonomous influences. The dynamics of changes in the concentrations of the identified set of proteins reveal that in cosmonauts with a predominance of sympathetic modulating influences, the mechanisms of autonomic regulation are exposed to significant stress in the recovery period immediately after the completion of the space mission, compared with the cosmonauts with a predominance of parasympathetic modulating influences.
该研究展示了对完成约6个月太空任务的宇航员血浆蛋白浓度变化与心率变异性（HRV）相关性的评估结果。对宇航员血浆生物样本中的125种蛋白质浓度进行了定量分析。利用生物信息资源（免疫球蛋白重链恒定μ、补体C1q亚成分亚基C、血浆丝氨酸蛋白酶抑制剂、72kDa IV型胶原酶、纤连蛋白-1、免疫球蛋白λ恒定区3）确定了与HRV自主调节生理过程相关的蛋白质亚组。在飞行前血浆中这些蛋白质的浓度，以及飞行后康复期第1天和第7天浓度变化的动态情况，在以交感或副交感调节自主影响为主的宇航员组中有所不同。所确定的一组蛋白质浓度变化动态表明，与以副交感调节影响为主的宇航员相比，以交感调节影响为主的宇航员在太空任务完成后的恢复期，自主调节机制受到显著压力。
