Laboratoire de Psychopathologie et Processus de Santé, Université de Paris, F-92100, Boulogne-Billacourt, France.
Department of Emergency Psychiatry and Acute Care, CHU Montpellier, Montpellier, France.
Eat Weight Disord. 2021 Dec;26(8):2645-2656. doi: 10.1007/s40519-021-01146-z. Epub 2021 Feb 13.
Ehlers-Danlos syndromes (EDS) are a group of heritable conditions in which abnormal collagen synthesis leads to features such as joint hypermobility, skin abnormalities, and tissue fragility. Gastrointestinal (GI) symptoms are common among those affected. These may negatively impact eating behaviors, leading to weight/nutritional problems. We aimed to compare GI symptoms, disordered eating, and body mass index (BMI) between EDS patients and healthy controls, and to explore the link between these variables in EDS patients.
In this cross-sectional study, women with EDS and healthy controls responded to an online survey assessing GI symptoms (heartburn/regurgitations, early satiety, nausea/vomiting, bloating, abdominal pain, dysphagia), food allergies/intolerances, disordered eating, history of eating disorders (ED), and BMI. We performed intergroup comparisons as well as multivariate analyses to explore the associations between disordered eating, GI symptoms, and BMI in the EDS group.
Sixty-six women with EDS and 39 healthy controls were included in the study. The EDS patients showed significantly more GI symptoms and food allergies/intolerances, increased prevalence of ED history, higher risk of current ED, and lower BMI than the controls. In the EDS group, the risk for ED was associated with GI symptoms; restricted eating was associated with GI symptoms, food allergies/intolerances, and dysphagia; uncontrolled eating was associated with GI symptoms; and BMI was associated with GI symptoms and food allergies/intolerances.
Our results are concordant with that of previous reports highlighting the high level of GI problems and disordered eating in women with EDS. In addition, and for the first-time, the association between both is evidenced in this specific population.
Case-control analytic study.
埃勒斯-当洛斯综合征（EDS）是一组遗传性疾病，其异常的胶原合成导致关节过度活动、皮肤异常和组织脆弱等特征。胃肠道（GI）症状在受影响者中很常见。这些症状可能会对饮食行为产生负面影响，导致体重/营养问题。我们旨在比较 EDS 患者和健康对照组的 GI 症状、饮食失调和体重指数（BMI），并探讨 EDS 患者中这些变量之间的联系。
在这项横断面研究中，患有 EDS 的女性和健康对照组通过在线调查回答了有关 GI 症状（烧心/反流、早饱、恶心/呕吐、腹胀、腹痛、吞咽困难）、食物过敏/不耐受、饮食失调、饮食失调史（ED）和 BMI 的问题。我们进行了组间比较和多变量分析，以探讨 EDS 组中饮食失调、GI 症状和 BMI 之间的关联。
本研究纳入了 66 名 EDS 女性和 39 名健康对照组。与对照组相比，EDS 患者的 GI 症状和食物过敏/不耐受明显更多，ED 病史的发生率更高，当前 ED 的风险更高，BMI 更低。在 EDS 组中，ED 的风险与 GI 症状相关；限制饮食与 GI 症状、食物过敏/不耐受和吞咽困难相关；失控饮食与 GI 症状相关；而 BMI 与 GI 症状和食物过敏/不耐受相关。
我们的结果与之前的报告一致，强调了 EDS 女性中高水平的 GI 问题和饮食失调。此外，这是首次在特定人群中证明了这两者之间的关联。
证据水平 III：病例对照分析研究。
