Laboratory of Psychopathology and Health Processes, Institut de Psychologie, University Paris Descartes-Sorbonne Paris Cité, 71 Avenue Édouard Vaillant, 92100, Boulogne-Billancourt, France.
INSERM U1061, Neuropsychiatry: Epidemiological and Clinical Research, Department of Emergency Psychiatry and Acute Care, CHU Montpellier, Montpellier, France.
Rheumatol Int. 2018 May;38(5):871-878. doi: 10.1007/s00296-018-4003-7. Epub 2018 Mar 1.
Despite the frequent co-ocurrence of hypermobile Ehler-Danlos syndrome (hEDS) and pathological anxiety, little is known about the psychosocial and health implications of such comorbidity. Our aim was to explore the association between high levels of anxiety and psychosocial (catastrophizing, kinesiophobia, somatosensory amplification, social support and functioning), health (pain, fatigue, BMI, tobacco/alcohol use, depression, diagnosis delay, general health), and sociodemographic factors in people with hEDS. In this cross-sectional study, 80 hEDS patients were divided into two groups according to self-reported anxiety levels: low and high. Psychosocial, sociodemographic and health variables were compared between the groups. Forty-one participants reported a high level of anxiety (51.2%). No differences were found in the sociodemographic variables between high-anxious and low-anxious patients. The percentage of participants with severe fatigue and high depressive symptomatology was significantly higher in the high-anxious group (80.5 vs 56.4; 26.8 vs 12.8%, respectively). High-anxious hEDS patients also showed significantly higher levels of pain catastrophizing, somatosensory amplification as well as a poorer social functioning and general health. Multivariate analyses showed that somatosensory amplification, pain catastrophizing and poor social functioning are variables that increase the probability of belonging to the high-anxious group. Despite limitations, this first study comparing high-anxious versus low-anxious hEDS patients with respect to health aspects, highlight the importance of considering the psychosocial factors (many susceptible to modification), to improve the adjustment to this chronic condition and provide support to those affected through a biopsychosocial approach.
尽管患有高活动性埃勒斯-当洛斯综合征（hEDS）和病理性焦虑症经常同时发生，但对于这种共病的心理社会和健康影响知之甚少。我们的目的是探讨高水平焦虑与 hEDS 患者的心理社会（灾难化、运动恐惧、躯体感觉放大、社会支持和功能）、健康（疼痛、疲劳、BMI、吸烟/饮酒、抑郁、诊断延迟、一般健康）和社会人口统计学因素之间的关联。在这项横断面研究中，根据自我报告的焦虑水平，将 80 名 hEDS 患者分为两组：低焦虑组和高焦虑组。比较了两组之间的心理社会、社会人口统计学和健康变量。41 名参与者报告了高水平的焦虑（51.2%）。高焦虑和低焦虑患者在社会人口统计学变量方面没有差异。高焦虑组严重疲劳和高抑郁症状的参与者比例明显更高（80.5%比 56.4%；26.8%比 12.8%）。高焦虑 hEDS 患者的疼痛灾难化、躯体感觉放大以及社会功能和一般健康状况也明显较差。多变量分析表明，躯体感觉放大、疼痛灾难化和较差的社会功能是增加属于高焦虑组的可能性的变量。尽管存在局限性，但这项首次比较高焦虑和低焦虑 hEDS 患者在健康方面的研究，强调了考虑心理社会因素（许多因素容易改变）的重要性，以改善对这种慢性疾病的适应，并通过生物心理社会方法为受影响者提供支持。
