Gerontopole of Toulouse, Institute of Aging, Toulouse University Hospital (CHU Toulouse), Toulouse, France.
CERPOP UMR 1295, University of Toulouse III. INSERM. UPS., Toulouse, France.
Aging Clin Exp Res. 2021 Nov;33(11):3135-3139. doi: 10.1007/s40520-021-01803-4. Epub 2021 Feb 13.
Based on clinical observations, our objective was to test if the older adults who failed to recall the name of the weekday, or had a higher number of mistakes in the word recall were at higher risk of mild cognitive impairment (MCI) or dementia. Longitudinal data of the Multidomain Alzheimer Preventive Trial (MAPT) was used to retrospectively measure the cognitive capacity according to the ICOPE Step 1 tool. Incident dementia was assessed by two multidisciplinary committees independent from each other. MCI was defined as Clinical Dementia Rating scale CDR = 0.5. Failure to recall the name of the weekday had a three-fold risk of incident dementia in the next 5 years (HRa = 3.11, 95%CI: 1.18-8.17). Having two or three mistakes in the word recall carried a higher risk of incident dementia, (HRa for two mistakes = 3.50, 95% CI: 1.49-8.26; HRa for three mistakes = 4.28, 95% CI: 1.60-11.46), but not MCI. People with impaired cognitive capacity according to the ICOPE Step 1 tool deserve further assessment and a closer follow-up.
基于临床观察,我们的目的是检验那些无法回忆出星期名称或在单词回忆测试中出现更多错误的老年人是否存在更高的轻度认知障碍(MCI)或痴呆风险。我们使用多领域阿尔茨海默病预防试验(MAPT)的纵向数据,根据 ICOPE 步骤 1 工具来回顾性测量认知能力。通过两个相互独立的多学科委员会评估新发痴呆。MCI 的定义为临床痴呆评定量表 CDR = 0.5。在接下来的 5 年内,无法回忆出星期名称的老年人发生痴呆的风险增加了三倍(HRa = 3.11,95%CI:1.18-8.17)。在单词回忆测试中出现两个或三个错误与发生痴呆的风险增加相关(出现两个错误的 HRa = 3.50,95%CI:1.49-8.26;出现三个错误的 HRa = 4.28,95%CI:1.60-11.46),但与 MCI 无关。根据 ICOPE 步骤 1 工具认知能力受损的患者需要进一步评估和密切随访。