Liu Meng-Yu, Chen Zhi-Ye, Li Jin-Feng, Xiao Hua-Feng, Ma Lin
Department of Radiology, First Medical Center of Chinese PLA General Hospital, Beijing, China.
Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China.
J Int Med Res. 2021 Feb;49(2):300060521992222. doi: 10.1177/0300060521992222.
To evaluate alterations in phase-shift values in the gray matter of patients with amyotrophic lateral sclerosis (ALS) using susceptibility-weighted imaging (SWI).
Twenty patients with definite or probable ALS and 19 age- and sex-matched healthy controls were enrolled. SWI was performed using a 3.0 T magnetic resonance imaging scanner. Phase-shift values were measured in corrected phase images using regions of interest, which were placed on the bilateral precentral gyrus, frontal cortex, caudate nucleus, globus pallidus, and putamen.
Phase-shift values of the precentral gyrus were significantly lower in ALS patients (-0.176 ± 0.050) than in the control group (-0.119 ± 0.016) on SWI. The average phase-shift values of the frontal cortex, caudate nucleus, globus pallidus, and putamen in ALS patients (-0.089 ± 0.023, -0.065 ± 0.016, -0.336 ± 0.191, and -0.227 ± 0.101, respectively) were not significantly different from those in the healthy controls (-0.885 ± 0.015, -0.079 ± 0.018, -0.329 ± 0.136, and -0.229 ± 0.083, respectively).
Compared with healthy controls, ALS patients had a lower phase-shift value in the precentral gyrus, which may be related to abnormal iron overload. Thus, SWI is a potential method for identifying ALS patients.
利用磁敏感加权成像（SWI）评估肌萎缩侧索硬化症（ALS）患者灰质的相位偏移值变化。
纳入20例确诊或疑似ALS患者以及19例年龄和性别匹配的健康对照者。使用3.0T磁共振成像扫描仪进行SWI检查。在经校正的相位图像上，使用感兴趣区域测量相位偏移值，感兴趣区域放置在双侧中央前回、额叶皮质、尾状核、苍白球和壳核上。
在SWI上，ALS患者中央前回的相位偏移值（-0.176±0.050）显著低于对照组（-0.119±0.016）。ALS患者额叶皮质、尾状核、苍白球和壳核的平均相位偏移值（分别为-0.089±0.023、-0.065±0.016、-0.336±0.191和-0.227±0.101）与健康对照组（分别为-0.885±0.015、-0.079±0.018、-0.329±0.136和-0.229±0.083）相比，差异无统计学意义。
与健康对照组相比，ALS患者中央前回的相位偏移值较低，这可能与铁过载异常有关。因此，SWI是识别ALS患者的一种潜在方法。
