Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao 266071, China; Institute of Brain Science and Disease, Qingdao University, Qingdao 266071, China.
Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao 266071, China; Institute of Brain Science and Disease, Qingdao University, Qingdao 266071, China.
Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):967-973. doi: 10.1016/j.bbadis.2018.01.008. Epub 2018 Jan 6.
Understandings of the disturbed iron metabolism in Parkinson's disease (PD) are largely from the perspectives of neurons. Neurodegenerative processes in PD trigger universal and conserved astroglial dysfunction and microglial activation. In this review, we start with astroglia and microglia in PD with an emphasis on their roles in spreading α-synuclein pathology, and then focus on their contributions in iron metabolism under normal conditions and the diseased state of PD. Elevated iron in the brain regions affects glial features, meanwhile, glial effects on neuronal iron metabolism are largely dependent on their releasing factors. These advances might be valuable for better understanding and modulating iron metabolism disturbance in PD.
帕金森病（PD）中紊乱的铁代谢的理解主要来自神经元的角度。PD 中的神经退行性过程引发普遍且保守的星形胶质细胞功能障碍和小胶质细胞激活。在这篇综述中，我们从 PD 中的星形胶质细胞和小胶质细胞开始，重点关注它们在传播α-突触核蛋白病理学中的作用，然后专注于它们在正常情况下和 PD 疾病状态下对铁代谢的贡献。大脑区域中升高的铁会影响神经胶质的特征，同时，神经胶质对神经元铁代谢的影响在很大程度上取决于它们释放的因子。这些进展可能有助于更好地理解和调节 PD 中的铁代谢紊乱。
