Zhao Jin, Ding Qiang, Li Lan, Kalds Peter, Zhou Shiwei, Sun Jiayuan, Huang Shuhong, Wang Xiaolong, Chen Yulin
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Anim Biotechnol. 2022 Nov;33(6):1198-1204. doi: 10.1080/10495398.2021.1881529. Epub 2021 Feb 13.
Keratin-associated proteins (KAPs) are important structural components of fibers that predominantly present in the ortho-cortex. These proteins form a cross-linked network with keratin intermediate filaments (KIFs), thus producing a strong hair shaft. The keratin-associated protein 6-1 gene () is a member of the KAPs family that has a potential correlation with fiber traits. In this study, we investigated the influence of sequence polymorphisms on the fiber characteristics of a Chinese cashmere-producing goat breed ( = 844). Two main variants were found, including a three base pair (bp) deletion (namely B) and a 36-bp deletion (namely C), while the reference genotype of was named A. Among them, the B variant was first reported on cashmere goats. This study then correlated these genotypes with the collected fiber data to investigate the potential association of these variants. The results showed that variant A is associated with decreased fiber diameter ( < 0.01), while variant C is associated with deceased fiber length ( < 0.01). These two related variants of the gene have potential applications as gene-makers to improve the fiber diameter and length in cashmere-producing goats.
角蛋白相关蛋白（KAPs）是主要存在于正皮质中的纤维的重要结构成分。这些蛋白质与角蛋白中间丝（KIFs）形成交联网络，从而产生坚固的毛干。角蛋白相关蛋白6-1基因（）是KAPs家族的成员，与纤维性状具有潜在相关性。在本研究中，我们调查了序列多态性对中国产绒山羊品种（n = 844）纤维特性的影响。发现了两个主要变体，包括一个三碱基对（bp）缺失（即B）和一个36 bp缺失（即C），而的参考基因型被命名为A。其中，B变体首次在绒山羊中报道。然后，本研究将这些基因型与收集到的纤维数据相关联，以研究这些变体的潜在关联。结果表明，变体A与纤维直径减小相关（P < 0.01），而变体C与纤维长度减小相关（P < 0.01）。该基因的这两个相关变体作为基因标记物在改善产绒山羊纤维直径和长度方面具有潜在应用价值。
