Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
College of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China.
Curr Drug Deliv. 2021;18(7):862-873. doi: 10.2174/1567201818666210212100633.
In the past few decades, drug-eluting stents have made significant contributions to the treatment of coronary heart disease. However, due to the delayed healing of endothelial injuries caused by antiproliferative drugs and insufficient biocompatibility of vascular stent materials, late in-stent thrombosis and restenosis remain major challenges. Surface modification of cardiovascular materials to construct a biological functional layer that can regulate the behavior of blood and vascular cells is an effective way to improve the clinical performance of vascular stents. This paper reviewed the common methods of surface bio-functional modification of cardiovascular materials and especially proposed that take advantage of the new concept of precision medicine, as well as the precise and orderly regulation properties of cardiovascular disease-related gene fragments on vascular biological response behavior, the construction of gene-eluting stents which can in-situ regulate vascular intimal repair at the molecular and genetic level will become an important research direction in the future.
在过去的几十年中，药物洗脱支架在冠心病的治疗中做出了重大贡献。然而，由于抗增殖药物导致的内皮损伤愈合延迟和血管支架材料的生物相容性不足，迟发性支架内血栓形成和再狭窄仍然是主要挑战。通过对心血管材料进行表面改性来构建可调节血液和血管细胞行为的生物功能层是改善血管支架临床性能的有效方法。本文综述了心血管材料表面生物功能改性的常见方法，并特别提出利用精准医学的新概念，以及心血管疾病相关基因片段对血管生物响应行为的精确有序调控特性，构建可在分子和遗传水平原位调节血管内膜修复的基因洗脱支架，将成为未来的一个重要研究方向。
