新生儿肉瘤的诊断和治疗进展。

Advances in the Diagnosis and Management of Neonatal Sarcomas.

机构信息

Pediatric Hematology/Oncology, Duke University School of Medicine, DUMC, Box 102382, Durham, NC 27710, USA.

Pediatric Hematology/Oncology, Duke University School of Medicine, DUMC, Box 3712, Durham, NC 27710, USA.

出版信息

Clin Perinatol. 2021 Mar;48(1):117-145. doi: 10.1016/j.clp.2020.11.007.

DOI:10.1016/j.clp.2020.11.007

PMID:33583500

Abstract

Neonatal sarcomas comprise a heterogeneous group of rare soft tissue neoplasms that present unique diagnostic and therapeutic challenges. Recent advances in molecular profiling have improved diagnostic capabilities and reveal novel therapeutic targets. Clinical trials demonstrate differences in behavior between sarcoma subtypes that allow for better clinical management. Surgical resection has been replaced with a multimodal approach that includes chemotherapy and radiotherapy. Despite these advances, neonates with sarcoma continue to fare worse than histologically similar sarcomas in older children, likely reflecting differences in tumor biology and the complexities of neonatal medicine. This review focuses on recent advances in managing neonatal sarcomas.

摘要

新生儿肉瘤是一组罕见的软组织肿瘤，具有独特的诊断和治疗挑战。分子谱分析的最新进展提高了诊断能力，并揭示了新的治疗靶点。临床试验表明，肉瘤亚型之间的行为存在差异，这有助于更好的临床管理。手术切除已被包括化疗和放疗在内的多模态方法所取代。尽管取得了这些进展，但患有肉瘤的新生儿的预后仍不如年龄较大的儿童中组织学相似的肉瘤，这可能反映了肿瘤生物学和新生儿医学复杂性的差异。本综述重点介绍了新生儿肉瘤管理的最新进展。