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本体研究中是否适用单病例随机对照试验?一项方法学先导试验带来的启示。

Is the N-of-1 method applicable in bodywork research? Lessons learned using a trial as a methodological pilot.

机构信息

Open University, University of Helsinki, Helsinki 00014, Finland.

出版信息

J Integr Med. 2021 May;19(3):203-210. doi: 10.1016/j.joim.2021.01.010. Epub 2021 Feb 2.

DOI:10.1016/j.joim.2021.01.010
PMID:33583758
Abstract

N-of-1 trial designs have rarely been used in bodywork research. Using a recent trial as a methodological pilot, critical issues related to the applicability of N-of-1 trials to bodywork are discussed. These include the issues of carry-over effects, bias-controlling approaches and statistical analysis. The discussion highlights the importance of mixed methods and draws some suggestions for a future research program. N-of-1 trials could be used to provide insights about some essential elements of bodywork modalities and their effectiveness.

摘要

N-of-1 试验设计在按摩研究中很少使用。本文以最近的一项试验为例进行方法学试点,讨论了 N-of-1 试验在按摩中的适用性相关的关键问题。这些问题包括交叉效应、偏倚控制方法和统计分析。讨论强调了混合方法的重要性,并为未来的研究计划提出了一些建议。N-of-1 试验可用于深入了解按摩方式的一些基本要素及其有效性。

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