Agricultural College, Yanbian University, Yanji, Jilin Province, China.
Key Laboratory of Natural Resource of Changbai Mountain and Functional Molecules (Ministry of Education), Yanbian University, Yanji, Jilin Province, China/Agricultural College, Yanbian University, Yanji, Jilin Province, China.
Pak J Pharm Sci. 2020 Jul;33(4):1473-1481.
Oenothera biennis L. is a perennial herb distributed across America, Asia, and Europe. The pharmacological effect of Oenothera biennis L. stem is poorly understood. We demonstrated that lipopolysaccharide (LPS)-induced the high production of inflammatory mediators nitric oxide (NO) and prostaglandin E2 (PGE2) and the pro-inflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β in peritoneal macrophages (PMs) were significantly inhibited by the crude extract The inflammation related signaling extra cellular signal-regulated ERK, P38 of MAPK and NF-kappaB (NF-κB) activated by LPS dramatically inhibited. In conclusion, our results suggested that the stems of Oenothera biennis L. possess a high anti-inflammatory property, thus, can be used in the industrial production of medicinal products as the raw material in the future.
月见草（Oenothera biennis L.）是一种多年生草本植物，分布于美洲、亚洲和欧洲。月见草茎的药理学作用尚未完全了解。我们证明，脂多糖（LPS）诱导的炎症介质一氧化氮（NO）和前列腺素 E2（PGE2）以及促炎细胞因子肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6 和 IL-1β在腹膜巨噬细胞（PMs）中的高产量显著受到粗提取物的抑制。LPS 激活的炎症相关信号细胞外信号调节激酶（ERK）、丝裂原活化蛋白激酶（MAPK）p38 和核因子-κB（NF-κB）受到显著抑制。总之，我们的结果表明，月见草的茎具有很强的抗炎特性，因此，将来可以用作医药产品工业生产的原料。
