Lin Chien-Hung, Chiu Hsienhsueh Elley, Wu Szu-Ying, Tseng Shih-Ting, Wu Tzu-Chan, Hung Yu-Chiang, Hsu Chung Y, Chen Hsuan-Ju, Hsu Sheng-Feng, Kuo Chun-En, Hu Wen-Long
Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Department of Nursing, Meiho University, Pingtung, Taiwan.
Front Pharmacol. 2021 Jan 27;11:615657. doi: 10.3389/fphar.2020.615657. eCollection 2020.
Combinations of Chinese herbal products (CHPs) are widely used for Parkinson's disease (PD) in Taiwan. Thereby, we investigated the use of CHPs in patients with PD. This study was a population-based cohort study that analyzed the data of patients with PD from the National Health Insurance Research Database. A total of 9,117 patients were selected from a random sample of one million individuals included in this database. We used multiple logistic regression models to estimate the adjusted odds ratios of the demographic factors and analyzed the formula and single CHPs commonly used for PD. Traditional Chinese medicine users were more commonly female, younger, of white-collar status, and residents of Central Taiwan. Chaihu-Jia-Longgu-Muli-Tang was the most commonly used formula, followed by Ma-Zi-Ren-Wan and then Shao-Yao-Gan-Cao-Tang. The most commonly used single herb was (Willd. ex Schult.) DC., followed by Blume and then ( L., Maxim ex Balf., Baill.). Chaihu-Jia-Longgu-Muli-Tang and (Willd. ex Schult.) DC have shown neuroprotective effects in previous studies, and they have been used for managing non-motor symptoms of PD. Chaihu-Jia-Longgu-Muli-Tang and (Willd. ex Schult.) DC are the most commonly used CHPs for PD in Taiwan. Our results revealed the preferences in medication prescriptions for PD. Further studies are warranted to determine the effectiveness of these CHPs for ameliorating the various symptoms of PD, their adverse effects, and the mechanisms underlying their associated neuroprotective effects.
中药复方在台湾被广泛用于治疗帕金森病（PD）。因此，我们对PD患者使用中药复方的情况进行了调查。本研究是一项基于人群的队列研究，分析了来自国民健康保险研究数据库中PD患者的数据。从该数据库中包含的100万个体的随机样本中选取了9117名患者。我们使用多元逻辑回归模型来估计人口统计学因素的调整比值比，并分析了常用于PD的方剂和单味中药。使用传统中药的患者更常见于女性、较年轻、白领身份以及台湾中部居民。柴胡加龙骨牡蛎汤是最常用的方剂，其次是麻子仁丸，然后是芍药甘草汤。最常用的单味中药是麻黄（Willd. ex Schult.）DC.，其次是薄荷Blume，然后是人参（L.，Maxim ex Balf.，Baill.）。柴胡加龙骨牡蛎汤和麻黄（Willd. ex Schult.）DC在先前的研究中已显示出神经保护作用，并且它们已被用于管理PD的非运动症状。柴胡加龙骨牡蛎汤和麻黄（Willd. ex Schult.）DC是台湾治疗PD最常用的中药复方。我们的结果揭示了PD药物处方的偏好。有必要进一步研究以确定这些中药复方改善PD各种症状的有效性、它们的不良反应以及其相关神经保护作用的潜在机制。
