Lyu Shaohua, Zhang Claire Shuiqing, Mao Zhenhui, Guo Xinfeng, Li Zhe, Luo Xiaodong, Sun Jingbo, Su Qiaozhen
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
School of Health and Biomedical Sciences, STEM College, RMIT University, Bundoora, VIC, Australia.
Front Aging Neurosci. 2024 May 2;16:1362948. doi: 10.3389/fnagi.2024.1362948. eCollection 2024.
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative condition. Chinese medicine therapies have demonstrated effectiveness for PD in controlled settings. However, the utilization of Chinese medicine therapies for PD in real-world clinical practice and the characteristics of patients seeking these therapies have not been thoroughly summarized. METHOD: The study retrospectively analyzed initial patient encounters (PEs) with a first-listed diagnosis of PD, based on electronic medical records from Guangdong Provincial Hospital of Chinese Medicine between July 2018 and July 2023. RESULTS: A total of 3,206 PEs, each corresponding to an individual patient, were eligible for analyses. Approximately 60% of patients made initial visits to the Chinese medicine hospital after receiving a PD diagnosis, around 4.59 years after the onset of motor symptoms. Over 75% of the patients visited the Internal Medicine Outpatient Clinic at their initial visits, while a mere 13.85% visited PD Chronic Care Clinic. Rest tremor (61.98%) and bradykinesia (52.34%) are the most commonly reported motor symptoms, followed by rigidity (40.70%). The most commonly recorded non-motor symptoms included constipation (31.88%) and sleep disturbance (25.27%). Integration of Chinese medicine and conventional medicine therapies was the most common treatment method (39.15%), followed by single use of Chinese herbal medicine (27.14%). The most frequently prescribed herbs for PD included Fisch. (), Bunge (), Koidz. (), (Oliv.) Diels (), (Gaertn.) DC. (), Pall. (), DC. (), L. (/), C. A. Mey. (), and (Schw.) Wolf (). These herbs contribute to formulation of (BZYQT). CONCLUSION: Patients typically initiated Chinese medical care after the establishment of PD diagnosis, ~4.59 years post-onset of motor symptoms. The prevalent utilization of CHM decoctions and patented Chinese herbal medicine products, underscores its potential in addressing both motor and non-motor symptoms. Despite available evidence, rigorous clinical trials are needed to validate and optimize the integration of CHM, particularly BZYQT, into therapeutic strategies for PD.
背景：帕金森病（PD）是一种进行性神经退行性疾病。中医治疗在对照研究中已显示出对帕金森病的有效性。然而，在实际临床实践中中医治疗帕金森病的应用情况以及寻求这些治疗的患者特征尚未得到全面总结。 方法：本研究基于广东省中医院2018年7月至2023年7月的电子病历，回顾性分析了以帕金森病为首要诊断的首次患者就诊情况。 结果：共有3206例符合分析条件的首次就诊患者，每位患者对应一次就诊。约60%的患者在被诊断为帕金森病后首次到中医院就诊，时间约在运动症状出现后4.59年。超过75%的患者首次就诊时前往内科门诊，而仅有13.85%的患者前往帕金森病慢病门诊。静止性震颤（61.98%）和运动迟缓（52.34%）是最常报告的运动症状，其次是僵硬（40.70%）。最常记录的非运动症状包括便秘（31.88%）和睡眠障碍（25.27%）。中西医结合治疗是最常见的治疗方法（39.15%），其次是单纯使用中药（27.14%）。帕金森病最常使用的中药包括 （此处原文部分药材名称缺失）。这些中药有助于组成 （补阳还五汤）。 结论：患者通常在帕金森病诊断确立后，即运动症状出现约4.59年后开始接受中医治疗。中药汤剂和中药专利产品的普遍使用，凸显了其在解决运动和非运动症状方面的潜力。尽管有现有证据，但仍需要严格的临床试验来验证并优化将中药，特别是补阳还五汤，纳入帕金森病治疗策略。
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