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卡介苗接种的中国人群中针对多种分枝杆菌抗原的年龄相关免疫反应特征。

Age-Related Immunoreactivity Profiles to Diverse Mycobacterial Antigens in BCG-Vaccinated Chinese Population.

机构信息

Department of Microbiology and Immunology, Shanghai Institute of Immunology, Shanghai Jiao Tong Unviersity School of Medicine, Shanghai, China.

Key Laboratory of Parasite and Vector Biology, Ministry of Health, School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Front Immunol. 2021 Jan 29;11:608220. doi: 10.3389/fimmu.2020.608220. eCollection 2020.

DOI:10.3389/fimmu.2020.608220
PMID:33584683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7878369/
Abstract

Long-term immunoreactivity to mycobacterial antigens in Bovis Calmette-Guérin (BCG)-vaccinated population is not well investigated. Herein, 361 volunteer healthy donors (HDs) with neonatal BCG vaccination from Shanghai region (China) were enrolled. They were subdivided into ESAT-6/CFP10 (E6C10) and ESAT-6/CFP10 (E6C10) groups based on gamma-interferon release assays (IGRAs). Three mycobacterial antigens, including Rv0934, Rv3006, and Rv3841, were subjected to the determination of immunoreactivity by ELISPOT assay. The immunoreactivities to three mycobacterial antigens were firstly compared among TB patients (N=39), E6C10 HDs (N=78, 21.61% of HDs) and E6C10 HDs (N=283, 78.39% of HDs). It was revealed that Rv3006 was dominant upon infection, while Rv3841 was likely to be more responsive upon latent TB infection. In E6C10 population, the immunoreactivity to Rv3841 maintained along with aging, whereas those to Rv3006 and Rv0934 attenuated in E6C10 HDs older than 45 years old. Our study implies the shift of dominant antigens at different infection statuses, providing the clues for the selection of mycobacterial antigens in vaccine development and precision revaccination in the future.

摘要

牛型结核分枝杆菌疫苗（BCG）接种人群中对分枝杆菌抗原的长期免疫反应尚未得到充分研究。在此，纳入了 361 名来自上海地区（中国）的具有新生儿 BCG 接种史的健康志愿者（HDs）。他们根据γ干扰素释放试验（IGRAs）分为 ESAT-6/CFP10（E6C10）和 ESAT-6/CFP10（E6C10）组。通过 ELISPOT 测定法检测了 3 种分枝杆菌抗原，包括 Rv0934、Rv3006 和 Rv3841。首先比较了结核病患者（N=39）、E6C10HDs（N=78，HDs 的 21.61%）和 E6C10HDs（N=283，HDs 的 78.39%）之间三种分枝杆菌抗原的免疫反应性。结果表明，Rv3006 在感染时占优势，而 Rv3841 可能在潜伏性结核病感染时更具反应性。在 E6C10 人群中，Rv3841 的免疫反应性随着年龄的增长而保持，而在年龄大于 45 岁的 E6C10HDs 中，Rv3006 和 Rv0934 的免疫反应性减弱。我们的研究表明，在不同的感染状态下，优势抗原发生了转变，为未来疫苗开发和精准复种中分枝杆菌抗原的选择提供了线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb0/7878369/91b389e2c546/fimmu-11-608220-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb0/7878369/55d84462f0d1/fimmu-11-608220-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb0/7878369/b12333d3de82/fimmu-11-608220-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb0/7878369/9c9e001e7652/fimmu-11-608220-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb0/7878369/91b389e2c546/fimmu-11-608220-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb0/7878369/55d84462f0d1/fimmu-11-608220-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb0/7878369/b12333d3de82/fimmu-11-608220-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb0/7878369/9c9e001e7652/fimmu-11-608220-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eb0/7878369/91b389e2c546/fimmu-11-608220-g004.jpg

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本文引用的文献

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