Ogawa R, Baidillah M R, Akita S, Takei M
Graduate School of Science & Eng., Dept. Mechanical Eng., Chiba University, Chiba, Japan.
Graduate School of Medicine, Dept. Reconstructive & Aesthetic Surgery, Chiba University, Chiba, Japan.
J Electr Bioimpedance. 2020 May 14;11(1):19-25. doi: 10.2478/joeb-2020-0004. eCollection 2020 Jan.
There is a strong need for a non-invasive measurement technique that is capable of accurately identifying the physiological condition change or heterogeneity of subcutaneous adipose tissue (SAT) by localizing the abnormalities within the compartment. This paper aims to investigate the feasibility of Electrical Impedance Tomography (EIT) to assess the interstitial fluid in subcutaneous adipose tissue as an enhancement method of bioelectrical impedance spectroscopy (BIS). Here, we demonstrate the preliminary result of EIT with a wearable 16 electrodes sensor. The image-based reference EIT with fat weighted threshold method is proposed. In order to evaluate the performance of our novel method, a physiological swelling experiment is conducted, and Multi-Frequency Bioelectrical Impedance Analysis (MFBIA) is also applied as a comparison with EIT results. The experimental results showed that the proposed method was able to distinguish the physiological swelling condition and effectively to remove the unexpected background noise. Furthermore, the conductivity variation in the subcutaneous layer had a good correlation with extracellular water volume change from MFBIA data; the correlation coefficient R = 0.927. It is concluded that the proposed method provides a significant prospect for SAT assessment.
迫切需要一种非侵入性测量技术，该技术能够通过定位皮下脂肪组织（SAT）隔室内的异常情况，准确识别其生理状况变化或异质性。本文旨在研究电阻抗断层成像（EIT）作为生物电阻抗光谱法（BIS）的一种增强方法来评估皮下脂肪组织间质液的可行性。在此，我们展示了使用可穿戴16电极传感器进行EIT的初步结果。提出了基于图像的脂肪加权阈值法参考EIT。为了评估我们新方法的性能，进行了生理肿胀实验，并且还应用多频生物电阻抗分析（MFBIA）与EIT结果进行比较。实验结果表明，所提出的方法能够区分生理肿胀状况，并有效地去除意外的背景噪声。此外，皮下层的电导率变化与MFBIA数据中的细胞外水量变化具有良好的相关性；相关系数R = 0.927。结论是，所提出的方法为SAT评估提供了重要前景。
