van Houdt Petra J, Yang Yingli, van der Heide Uulke A
Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Department of Radiation Oncology, University of California, Los Angeles, CA, United States.
Front Oncol. 2021 Jan 29;10:615643. doi: 10.3389/fonc.2020.615643. eCollection 2020.
MRI-guided radiotherapy systems have the potential to bring two important concepts in modern radiotherapy together: adaptive radiotherapy and biological targeting. Based on frequent anatomical and functional imaging, monitoring the changes that occur in volume, shape as well as biological characteristics, a treatment plan can be updated regularly to accommodate the observed treatment response. For this purpose, quantitative imaging biomarkers need to be identified that show changes early during treatment and predict treatment outcome. This review provides an overview of the current evidence on quantitative MRI measurements during radiotherapy and their potential as an imaging biomarker on MRI-guided radiotherapy systems.
磁共振成像(MRI)引导的放射治疗系统有潜力将现代放射治疗中的两个重要概念结合起来:自适应放射治疗和生物靶向治疗。基于频繁的解剖学和功能成像,监测体积、形状以及生物学特征方面发生的变化,可以定期更新治疗计划以适应观察到的治疗反应。为此,需要识别出在治疗早期显示变化并预测治疗结果的定量成像生物标志物。本综述概述了放射治疗期间定量MRI测量的当前证据及其作为MRI引导放射治疗系统成像生物标志物的潜力。