Singh Yogesh, Salker Madhuri S, Lang Florian
Institute of Medical Genetics and Applied Genomics, Eberhard Karls University, Tübingen, Germany.
Women's Hospital, Eberhard Karls University, Tübingen, Germany.
Front Nutr. 2021 Jan 28;7:616934. doi: 10.3389/fnut.2020.616934. eCollection 2020.
Polyphenol compounds found in green tea have a great therapeutic potential to influence multiple human diseases including malignancy and inflammation. In this mini review, we describe effects of green tea and the most important component EGCG in malignancy and inflammation. We focus on cellular mechanisms involved in the modification of T cell function by green tea polyphenol EGCG. The case is made that EGCG downregulates calcium channel activity by influencing miRNAs regulating expression of the channel at the post-transcriptional level.
绿茶中发现的多酚化合物在影响包括恶性肿瘤和炎症在内的多种人类疾病方面具有巨大的治疗潜力。在这篇小型综述中，我们描述了绿茶及其最重要的成分表没食子儿茶素没食子酸酯（EGCG）在恶性肿瘤和炎症方面的作用。我们重点关注绿茶多酚EGCG修饰T细胞功能所涉及的细胞机制。有证据表明，EGCG通过影响在转录后水平调节该通道表达的微小RNA（miRNA）来下调钙通道活性。
