Tea Research Institute, Zhejiang University, Hangzhou 310058, China.
Intellectual Property Office of Lanshan District, Rizhao 543003, China.
Molecules. 2018 Sep 13;23(9):2346. doi: 10.3390/molecules23092346.
Many in vitro studies have shown that tea catechins had vevarious health beneficial effects. However, inconsistent results between in vitro and in vivo studies or between laboratory tests and epidemical studies are observed. Low bioavailability of tea catechins was an important factor leading to these inconsistencies. Research advances in bioavailability studies involving absorption and metabolic biotransformation of tea catechins were reviewed in the present paper. Related techniques for improving their bioavailability such as nanostructure-based drug delivery system, molecular modification, and co-administration of catechins with other bioactives were also discussed.
许多体外研究表明，茶儿茶素有多种有益健康的作用。然而，在体外和体内研究之间，或在实验室测试和流行病学研究之间，观察到的结果并不一致。茶儿茶素的生物利用度低是导致这些不一致的一个重要因素。本文综述了涉及茶儿茶素吸收和代谢生物转化的生物利用度研究进展。还讨论了提高其生物利用度的相关技术，如基于纳米结构的药物传递系统、分子修饰以及儿茶素与其他生物活性物质的共同给药。
