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机器人技术、微流控技术、纳米技术和人工智能在脂质体和聚合物药物传递系统的合成和评价中的应用。

Robotics, microfluidics, nanotechnology and AI in the synthesis and evaluation of liposomes and polymeric drug delivery systems.

机构信息

Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion - Israel Institute of Technology, 32000, Haifa, Israel.

出版信息

Drug Deliv Transl Res. 2021 Apr;11(2):345-352. doi: 10.1007/s13346-021-00929-2. Epub 2021 Feb 13.

Abstract

The field of nanotechnology and personalised medicine is undergoing drastic changes in the approach and efficiency of experimentation. The COVID-19 pandemic has spiralled into mass stagnation of major laboratories around the globe and led to increased investment into remote systems for nanoparticle experiments. A significant number of laboratories now operate using automated systems; however, the extension to nanoparticle preparation and artificial intelligence-dependent databases holds great translational promise. The strive to combine automation with artificial intelligence (AI) grants the ability to optimise targeted therapeutic nanoparticles for unique cell types and patients. In this perspective, the current and future trends of automated approaches to nanomedicine synthesis are discussed and compared with traditional methods.

摘要

纳米技术和个性化医学领域在实验方法和效率方面正在发生巨大变化。COVID-19 大流行导致全球主要实验室大规模停滞不前,并促使人们加大对远程纳米粒子实验系统的投资。现在,许多实验室都使用自动化系统进行操作;然而,纳米粒子制备和人工智能相关数据库的扩展具有很大的转化前景。将自动化与人工智能(AI)相结合的努力,使我们能够为独特的细胞类型和患者优化靶向治疗纳米粒子。在这篇观点文章中,讨论了自动化纳米医学合成方法的当前和未来趋势,并与传统方法进行了比较。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e493/7882236/6bd02e336d05/13346_2021_929_Fig1_HTML.jpg

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