Ma Zhen, Li Ming, Wang Xue-Sheng, Wang Qiang, Yuan Ming-Zhen
Department of Urology, Shandong Provincial Hospital, Shandong, China.
Shandong University, Jinan, China.
Andrologia. 2021 May;53(4):e13994. doi: 10.1111/and.13994. Epub 2021 Feb 14.
This study aimed to explore the efficacy of injection of micronised acellular dermal matrix (MADM) particles for treating primary premature ejaculation. This study was a prospective single-arm clinical trial. Thirty patients who met the surgical indications were enrolled. MADM particles, mixed in platelet-rich plasma, were injected into Buck's fascia to spread over the dorsal penile nerve, suppress the influx of nerve impulses and, thus, reduce penis sensitivity. We evaluated the changes according to intravaginal ejaculation latency time using a stopwatch and a premature ejaculation diagnostic tool. Meanwhile, we also recorded sexual partner satisfaction and adverse events. All patients recovered well after surgery with no complications such as infections or allergies. The mean intravaginal ejaculation latency time before surgery was 0.72 ± 0.28 min, compared with 2.41 ± 0.54 min, 2.64 ± 0.41 min, 2.79 ± 0.25 min and 2.89 ± 0.35 min at, respectively, 4, 8, 16 and 20 weeks after surgery. The premature ejaculation diagnostic values and sexual partner satisfaction had significantly improved after treatment. Injection of MADM particles is an effective, safe and simple method for treating premature ejaculation.
本研究旨在探讨注射微粉化脱细胞真皮基质（MADM）颗粒治疗原发性早泄的疗效。本研究为前瞻性单臂临床试验。纳入了30例符合手术指征的患者。将MADM颗粒与富血小板血浆混合后，注射至阴茎筋膜以覆盖阴茎背神经，抑制神经冲动传入，从而降低阴茎敏感性。我们使用秒表和早泄诊断工具，根据阴道内射精潜伏期评估变化情况。同时，我们还记录了性伴侣满意度和不良事件。所有患者术后恢复良好，未出现感染或过敏等并发症。术前阴道内射精潜伏期的平均值为0.72±0.28分钟，术后4周、8周、16周和20周分别为2.41±0.54分钟、2.64±0.41分钟、2.79±0.25分钟和2.89±0.35分钟。治疗后早泄诊断值和性伴侣满意度均有显著改善。注射MADM颗粒是一种治疗早泄的有效、安全且简便的方法。
