Shi Bentao, Li Xuesong, Chen Jing, Su Boxing, Li Xianxin, Yang Shangqi, Guan Zhichen, Wang Run
Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Int J Urol. 2014 Sep;21(9):923-6. doi: 10.1111/iju.12471. Epub 2014 Jun 10.
To evaluate the efficacy of resiniferatoxin in the treatment of patients with lifelong premature ejaculation.
A total of 41 outpatients (mean age 26.14 ± 4 years) with premature ejaculation completed the present study. They were randomly separated into the resiniferatoxin group and the placebo group. The resiniferatoxin group included 11 patients with redundant prepuce and 10 patients without redundant prepuce, whereas the placebo group contained 10 patients with redundant prepuce and 10 patients without. For the treatment, the glans were respectively soaked in 30 mL of resiniferatoxin with a concentration of 100 nmol/L or 10% alcohol solution for 30 min before sexual intercourse. Clinical efficacy was assessed by using the Chinese Index of Sexual Function for Premature Ejaculation-5 and the intravaginal ejaculation latency time before or 4 weeks after the treatment. The side-effects were also evaluated.
In the resiniferatoxin group, the effective rate of patients with redundant prepuce was 63.6%, and both the intravaginal ejaculation latency time and Chinese Index of Sexual Function for Premature Ejaculation-5 significantly increased (P < 0.05). However, the effective rate of patients without redundant prepuce was 20%, and there were no significant changes of their intravaginal ejaculation latency time and Chinese Index of Sexual Function for Premature Ejaculation-5 before and after the resiniferatoxin treatment (P > 0.05). The total effective rate of patients treated with resiniferatoxin was 42.9%. In the placebo group, the effective rate of patients with or without redundant prepuce was 20% and 10%, respectively. The total effective rate of patients treated with placebo was 15%, and there were no significant changes of their intravaginal ejaculation latency time and Chinese Index of Sexual Function for Premature Ejaculation-5 before and after the placebo treatment (P > 0.05). The side-effects included a slight burning sensation for the glans penis and dysuria.
These preliminary results show that resiniferatoxin might be suitable for treating patients with lifelong premature ejaculation and particularly those with redundant prepuce.
评估树脂毒素治疗终生性早泄患者的疗效。
共有41例早泄门诊患者（平均年龄26.14±4岁）完成本研究。他们被随机分为树脂毒素组和安慰剂组。树脂毒素组包括11例包皮过长患者和10例无包皮过长患者，而安慰剂组包含10例包皮过长患者和10例无包皮过长患者。治疗时，在性交前将龟头分别浸泡于30 mL浓度为100 nmol/L的树脂毒素或10%酒精溶液中30分钟。通过使用中国早泄性功能指数-5和治疗前或治疗4周后的阴道内射精潜伏期来评估临床疗效。同时也对副作用进行了评估。
在树脂毒素组中，包皮过长患者的有效率为63.6%，阴道内射精潜伏期和中国早泄性功能指数-5均显著增加（P<0.05）。然而，无包皮过长患者的有效率为20%，树脂毒素治疗前后其阴道内射精潜伏期和中国早泄性功能指数-5无显著变化（P>0.05）。接受树脂毒素治疗患者的总有效率为42.9%。在安慰剂组中，有或无包皮过长患者的有效率分别为20%和10%。接受安慰剂治疗患者的总有效率为15%，安慰剂治疗前后其阴道内射精潜伏期和中国早泄性功能指数-5无显著变化（P>0.05）。副作用包括阴茎头轻微烧灼感和排尿困难。
这些初步结果表明，树脂毒素可能适用于治疗终生性早泄患者，尤其是那些包皮过长的患者。
