孤立性血管环在高产前检出率时代：人口统计学、诊断、危险因素和结局。
Isolated vascular rings in the era of high prenatal detection rates: Demographics, diagnosis, risk factors, and outcome.
机构信息
Children's Heart Center Nevada, Las Vegas, Nevada, USA.
Department of Pediatrics, School of Medicine, Division of Pediatric Cardiology, University of Nevada Las Vegas, Las Vegas, Nevada, USA.
出版信息
J Card Surg. 2021 Apr;36(4):1381-1388. doi: 10.1111/jocs.15414. Epub 2021 Feb 14.
OBJECTIVE
We reviewed our center's isolated vascular ring data.
METHODS
Inclusion criteria were patients born in Nevada between June 2015 and July 2020 with situs solitus, levocardia, atrioventricular and ventriculoarterial concordance, and no significant intracardiac malformations.
RESULTS
We identified 95 patients. Of the 95, 56 (59%) were female (p = .033). For the study period, there were approximately 180,000 live births, for a prevalence of 5.3 isolated vascular rings per 10,000 live births. Of the 95, 78 (82%) were prenatally diagnosed. Of the 95, 63 (66%) were products of high-risk pregnancies (p = .0001). Additionally, we found advanced maternal age was an isolated vascular ring risk factor (relative risk ratio, 2.7; 95% confidence interval, 1.8, 4.1; p < .00001).
CONCLUSIONS
Isolated vascular rings are relatively common cardiovascular malformations and more common in females. High prenatal detection rates are achievable. Further, the majority with isolated vascular rings are products of high-risk pregnancies, and advanced maternal age is a statistically significant occurrence risk factor.
目的
我们回顾了本中心孤立性血管环的数据。
方法
纳入标准为 2015 年 6 月至 2020 年 7 月期间在内华达州出生、具有正位心、左心耳、房室和室动一致以及无明显心内畸形的患者。
结果
我们共确定了 95 例患者。其中 56 例（59%）为女性（p=0.033）。在研究期间，约有 180000 例活产儿，每 10000 例活产儿中就有 5.3 例孤立性血管环。95 例患者中，78 例（82%）为产前诊断。95 例患者中，63 例（66%）为高危妊娠（p=0.0001）。此外，我们发现高龄产妇是孤立性血管环的一个危险因素（相对风险比，2.7；95%置信区间，1.8，4.1；p<0.00001）。
结论
孤立性血管环是相对常见的心血管畸形，在女性中更为常见。可以实现较高的产前检出率。此外，大多数孤立性血管环患者均来自高危妊娠，而高龄产妇是一个具有统计学意义的发生风险因素。
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