Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Department of Internal Medicine, Tokyo Metropolitan, Komagome Hospital, Tokyo, Japan.
J Hepatobiliary Pancreat Sci. 2021 Mar;28(3):235-242. doi: 10.1002/jhbp.913. Epub 2021 Feb 26.
Several years have passed since the clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2012 were published. New findings and knowledge have accumulated since then. The Research Committees for IgG4-related Diseases and for Intractable Diseases of the Liver and Biliary Tract, in association with the Ministry of Health, Labor, and Welfare of Japan and the Japan Biliary Association, have established a working group consisting of researchers specializing in IgG4-SC and have drawn up new clinical diagnostic criteria for IgG4-SC 2020. The diagnosis of IgG4-SC is based on a combination of the following six criteria: (a) narrowing of the intra- or extrahepatic bile duct; (b) thickening of the bile duct wall; (c) serological findings; (d) pathological findings; (e) other organ involvement; and (f) effectiveness of steroid therapy. These new diagnostic criteria for IgG4-SC are useful in practice for general physicians and other non-specialists.
自 2012 年 IgG4 相关硬化性胆管炎的临床诊断标准公布以来，已经过去了几年。自那时以来，已经积累了新的发现和知识。日本厚生劳动省、日本肝胆胰疾病研究协会的 IgG4 相关疾病研究委员会和难治性肝胆疾病研究委员会联合成立了一个由专门研究 IgG4-SC 的研究人员组成的工作组，并制定了 2020 年 IgG4-SC 的新临床诊断标准。IgG4-SC 的诊断基于以下六个标准的组合：(a) 肝内外胆管狭窄；(b) 胆管壁增厚；(c) 血清学发现；(d) 病理学发现；(e) 其他器官受累；和 (f) 类固醇治疗的效果。这些 IgG4-SC 的新诊断标准对于普通医生和其他非专家来说在实践中是有用的。
