Barcelona-Estaje Eva, Dalby Matthew J, Cantini Marco, Salmeron-Sanchez Manuel
Centre for the Cellular Microenvironment, University of Glasgow, Glasgow, G12 8QQ, UK.
Adv Healthc Mater. 2021 Mar;10(6):e2002048. doi: 10.1002/adhm.202002048. Epub 2021 Feb 15.
While much work has been done in the design of biomaterials to control integrin-mediated adhesion, less emphasis has been put on functionalization of materials with cadherin ligands. Yet, cell-cell contacts in combination with cell-matrix interactions are key in driving embryonic development, collective cell migration, epithelial to mesenchymal transition, and cancer metastatic processes, among others. This review focuses on the incorporation of both cadherin and integrin ligands in biomaterial design, to promote what is called the "adhesive crosstalk." First, the structure and function of cadherins and their role in eliciting mechanotransductive processes, by themselves or in combination with integrin mechanosensing, are introduced. Then, biomaterials that mimic cell-cell interactions, and recent applications to get insights in fundamental biology and tissue engineering, are critically discussed.
虽然在生物材料设计中为控制整联蛋白介导的黏附已经做了很多工作，但对用钙黏蛋白配体对材料进行功能化的重视程度较低。然而，细胞间接触与细胞-基质相互作用相结合是驱动胚胎发育、集体细胞迁移、上皮-间充质转化和癌症转移过程等的关键。本综述着重于在生物材料设计中同时引入钙黏蛋白和整联蛋白配体，以促进所谓的“黏附串扰”。首先，介绍了钙黏蛋白的结构和功能及其在引发机械转导过程中的作用，这些作用可以单独发生，也可以与整联蛋白机械传感相结合。然后，对模拟细胞间相互作用的生物材料以及近期在基础生物学和组织工程中获得见解的应用进行了批判性讨论。
