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[创建国家内分泌疾病个性化医疗中心的前景]

[The prospects for the creation of the National Center for Personalized Medicine of Endocrine Diseases].

作者信息

Dedov I I, Mokrysheva N G, Shestakova M V, Volchkov P Y, Mayorov A Y, Rebrova O Yu, Barysheva V O, Krupinova Ju A, Troshina E A, Dzeranova L K, Melnichenko G A

机构信息

Endocrinology Research Centre.

出版信息

Probl Endokrinol (Mosk). 2021 Jan 26;67(1):13-19. doi: 10.14341/probl12730.

Abstract

The National Medical Research Center for Endocrinology (NMRCE) received the right to implement the development program of the World-class Research Centre "The National Center for personalized medicine of endocrine diseases" (NMCPMED). The objective of the NMCPMED will be not only the creation of a system of personalized treatment, but also the training of new specialists for medicine.  Fundamental researches, carried out on the basis of the already existing institutes and laboratories of the NMRCE will be expanded by creating new laboratories of the NCPMED created de novo in accordance with the approved project. This article introduces the reader to the most important laboratories that would be created in NCPMED. These are laboratories of general, molecular and population genetics, bioinformatics, pharmacogenomics, microbiota, genome editing, mathematical and digital technologies, non-invasive technologies for the diagnosis of endocrinopathies, cellular technologies, artificial intelligence and a fundamentally new laboratory of metabolic visualization and radioteranostics. The authors hope that readers of one of the main journals for endocrinologists in our country will actively participate in the  implementation of NMRCE, as both young and experienced talented researchers will have a chance to be a part of the Centre. To realize the ambitious implementation plans for the achievements of the Centre, it is necessary to radically change the worldview of the doctors in our country, to train them in a new way, and to expand the structure of the Center's team by increasing the number of specialists in medical genetics, transcriptomics, biostatistics and bioinformatics, working at the intersection of experimental and clinical endocrinology, and ensuring the transit of innovative technologies into clinical practice. New laboratories of the World-Class Research Center, will become the place of routine work of a new generation of doctors, who possess not only the basics of clinical work, but also the skills of fundamental researches that will allow them to significantly improve the methods of diagnosis and treatment.

摘要

国家内分泌医学研究中心(NMRCE)获得了实施世界级研究中心“国家内分泌疾病个性化医学中心”(NMCPMED)发展计划的权利。NMCPMED的目标不仅是创建个性化治疗体系,还包括培养医学新专家。将在NMRCE现有研究所和实验室基础上开展的基础研究,将通过按照获批项目全新创建NCPMED的新实验室来加以扩展。本文向读者介绍将在NCPMED创建的最重要的实验室。这些实验室包括普通遗传学、分子遗传学和群体遗传学实验室、生物信息学实验室、药物基因组学实验室、微生物群实验室、基因组编辑实验室、数学和数字技术实验室、内分泌疾病无创诊断技术实验室、细胞技术实验室、人工智能实验室以及一个全新的代谢可视化和放射治疗诊断学实验室。作者希望我国内分泌学家主要期刊之一的读者能积极参与NMRCE的实施,因为年轻和经验丰富的优秀研究人员都将有机会成为该中心的一员。为实现该中心宏伟的实施计划以取得成果,有必要从根本上改变我国医生的世界观,以新的方式培养他们,通过增加医学遗传学、转录组学、生物统计学和生物信息学专家的数量来扩大中心团队的结构,这些专家在实验和临床内分泌学的交叉领域工作,并确保创新技术转化为临床实践。世界级研究中心的新实验室将成为新一代医生日常工作的场所,他们不仅具备临床工作的基础,还拥有基础研究技能,这将使他们能够显著改进诊断和治疗方法。

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