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新冠后关节炎:病例报告及文献复习。

Post-COVID-19 arthritis: a case report and literature review.

机构信息

Rheumatology Unit, Department of Medicine-DIMED, University of Padua, Padua, Italy.

Internal Medicine Unit and Regional Liver Disease Reference Centre, Department of Medicine - DIMED, University of Padua, Padua, Italy.

出版信息

Clin Rheumatol. 2021 Aug;40(8):3357-3362. doi: 10.1007/s10067-020-05550-1. Epub 2021 Feb 15.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is the novel pathogen responsible for the coronavirus disease 19 (COVID-19) outbreak. Researchers and clinicians are exploring the pathogenetic mechanisms of the viral-induced damage and growing interest is focusing on the short-term and long-term immune-mediated consequences triggered by the infection. We will focus on post-SARS-CoV2 infection arthritis which may arise as a new pathological condition associated with COVID-19. In this article, we describe a case of acute oligoarthritis occurring 13 days after a SARS-CoV2 severe pneumonia in a middle-aged Caucasian man and we go over a brief review of the current available literature. We hypothesize that molecular mimicry might be the basic immunological mechanism responsible for the onset of COVID-19-related arthritis based on the current knowledge of SARS-CoV2 and on the known pathogenetic mechanism of viral-induced arthritis.

摘要

严重急性呼吸综合征冠状病毒 2(SARS-CoV2)是导致 2019 年冠状病毒病(COVID-19)爆发的新型病原体。研究人员和临床医生正在探索病毒引起的损伤的发病机制,越来越多的兴趣集中在感染引发的短期和长期免疫介导的后果上。我们将关注 SARS-CoV2 感染后关节炎,这可能是一种与 COVID-19 相关的新病理状况。在本文中,我们描述了一例中年白人男性 SARS-CoV2 重症肺炎后 13 天发生的急性寡关节炎,并简要回顾了目前可获得的文献。基于目前对 SARS-CoV2 的了解和已知的病毒引起的关节炎发病机制,我们假设分子模拟可能是导致 COVID-19 相关关节炎发生的基本免疫学机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4632/8289761/f3b5b5a20737/10067_2020_5550_Fig1_HTML.jpg

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