用于抗菌和伤口愈合目的的姜黄素纳米制剂。

Curcumin nanoformulations for antimicrobial and wound healing purposes.

作者信息

Salehi Bahare, Rodrigues Célia F, Peron Gregorio, Dall'Acqua Stefano, Sharifi-Rad Javad, Azmi Lubna, Shukla Ila, Singh Baghel Uttam, Prakash Mishra Abhay, Elissawy Ahmed M, Singab Abdel Nasser, Pezzani Raffaele, Redaelli Marco, Patra Jayanta Kumar, Kulandaisamy Venil Chidambaram, Das Gitishree, Singh Deeksha, Kriplani Priyanka, Venditti Alessandro, Fokou Patrick Valere Tsouh, Iriti Marcello, Amarowicz Ryszard, Martorell Miquel, Cruz-Martins Natália

机构信息

Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Porto, Portugal.

出版信息

Phytother Res. 2021 May;35(5):2487-2499. doi: 10.1002/ptr.6976. Epub 2021 Feb 15.

DOI:10.1002/ptr.6976

PMID:33587320

Abstract

The development and spread of resistance to antimicrobial drugs is hampering the management of microbial infectious and wound healing processes. Curcumin is the most active and effective constituent of Curcuma longa L., also known as turmeric, and has a very long and strong history of medicinal value for human health and skincare. Curcumin has been proposed as strong antimicrobial potentialities and many attempts have been made to determine its ability to conjointly control bacterial growth and promote wound healing. However, low aqueous solubility, poor tissue absorption and short plasma half-life due its rapid metabolism needs to be solved for made curcumin formulations as suitable treatment for wound healing. New curcumin nanoformulations have been designed to solve the low bioavailability problem of curcumin. Thus, in the present review, the therapeutic applications of curcumin nanoformulations for antimicrobial and wound healing purposes is described.

摘要

抗菌药物耐药性的发展和传播正阻碍着微生物感染的管理及伤口愈合过程。姜黄素是姜黄（Curcuma longa L.）中最具活性和效力的成分，姜黄也被称为姜黄根粉，在对人类健康和皮肤护理的药用价值方面有着悠久且显著的历史。姜黄素已被认为具有强大的抗菌潜力，并且人们已进行了许多尝试来确定其联合控制细菌生长和促进伤口愈合的能力。然而，由于其快速代谢导致的低水溶性、差的组织吸收和短的血浆半衰期，需要加以解决才能使姜黄素制剂成为适合伤口愈合的治疗方法。已设计出新的姜黄素纳米制剂来解决姜黄素生物利用度低的问题。因此，在本综述中，描述了姜黄素纳米制剂在抗菌和伤口愈合方面的治疗应用。