Tejada Silvia, Manayi Azadeh, Daglia Maria, Nabavi Seyed F, Sureda Antoni, Hajheydari Zohreh, Gortzi Olga, Pazoki-Toroudi Hamidreza, Nabavi Seyed M
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, P.O. Box 19395-5487, Iran.
Curr Pharm Biotechnol. 2016;17(11):1002-7. doi: 10.2174/1389201017666160721123109.
Wound healing is a complex process that consists of several phases that range from coagulation, inflammation, accumulation of radical substances, to proliferation, formation of fibrous tissues and collagen, contraction of wound with formation of granulation tissue and scar. Since antiquity, vegetable substances have been used as phytotherapeutic agents for wound healing, and more recently natural substances of vegetable origin have been studied with the attempt to show their beneficial effect on wound treatment. Curcumin, the most active component of rhizome of Curcuma longa L. (common name: turmeric), has been studied for many years due to its bio-functional properties, especially antioxidant, radical scavenger, antimicrobial and anti-inflammatory activities, which play a crucial role in the wound healing process. Moreover, curcumin stimulated the production of the growth factors involved in the wound healing process, and so curcumin also accelerated the management of wound restoration. The aim of the present review is collecting and evaluating the literature data regarding curcumin properties potentially relevant for wound healing. Moreover, the investigations on the wound healing effects of curcumin are reported. In order to produce a more complete picture, the chemistry and sources of curcumin are also discussed.
伤口愈合是一个复杂的过程，包括从凝血、炎症、自由基物质积累到增殖、纤维组织和胶原蛋白形成、伤口收缩以及肉芽组织和瘢痕形成等几个阶段。自古以来，植物性物质就被用作伤口愈合的植物治疗剂，最近，人们对植物来源的天然物质进行了研究，试图证明它们在伤口治疗中的有益作用。姜黄素是姜黄（俗称：姜黄）根茎中最活跃的成分，由于其生物功能特性，特别是抗氧化、自由基清除、抗菌和抗炎活性，在伤口愈合过程中起着至关重要的作用，因此已经被研究了很多年。此外，姜黄素刺激了伤口愈合过程中涉及的生长因子的产生，因此姜黄素也加速了伤口修复的进程。本综述的目的是收集和评估有关姜黄素与伤口愈合潜在相关特性的文献数据。此外，还报道了关于姜黄素伤口愈合效果的研究。为了呈现更完整的情况，还讨论了姜黄素的化学性质和来源。
