甲状腺素对大鼠雌激素依赖性垂体肿瘤（MtT/F84）中雌激素受体水平的影响。（原英文标题表意有误，推测这里想表达的是甲状腺素对雌激素受体水平的影响，而不是单纯的雌激素受体水平增加，所以翻译为这样一个更符合语境逻辑的句子。若仅按字面翻译为“甲状腺素使大鼠雌激素依赖性垂体肿瘤（MtT/F84）中雌激素受体水平增加”不太准确，因为英文标题里没有明确表明是“使……增加”这样的使动关系，只是“increase of...”这样宽泛的表达。）你可根据实际需求进行调整，如果还有其他疑问欢迎随时向我提问。按照要求的格式则为：甲状腺素对大鼠雌激素依赖性垂体肿瘤（MtT/F84）中雌激素受体水平的影响。

Increase of estrogen receptor level by thyroxine in estrogen dependent pituitary tumor (MtT/F84) in rats.

作者信息

Fujimoto N, Roy B, Watanabe H, Ito A

机构信息

Department of Cancer Research, Hiroshima University, Japan.

出版信息

Biochem Biophys Res Commun. 1988 Apr 15;152(1):44-8. doi: 10.1016/s0006-291x(88)80677-6.

DOI:10.1016/s0006-291x(88)80677-6

PMID:3358770

Abstract

A rat transplantable pituitary tumor, MtT/F84, grows much faster in E2 treated rats than in normal females, but is much retarded in thyroidectomized rats. Triiodothyronine (T3) administration in a drinking water increased the tumor growth by the dose dependent manner. The tumor contained both estrogen receptor (ER) and T3 receptor. ER levels both in the nuclei and cytosols elevated 2 to 3 times by the T3 administration compared to those of control. E2 administration promotes the growth of MtT/F84 through elevation of nuclear ER level. T3 may directly elevate cellular ER level and thus it may enhance estrogenic actions including the tumor growth.

摘要

一种可移植的大鼠垂体肿瘤MtT/F84，在经雌激素（E2）处理的大鼠中生长速度比正常雌性大鼠快得多，但在甲状腺切除的大鼠中生长则受到很大抑制。通过在饮用水中给予三碘甲状腺原氨酸（T3），肿瘤生长呈剂量依赖性增加。该肿瘤同时含有雌激素受体（ER）和T3受体。与对照组相比，给予T3后，细胞核和细胞质中的ER水平升高了2至3倍。给予E2通过提高细胞核ER水平促进MtT/F84的生长。T3可能直接提高细胞ER水平，从而可能增强包括肿瘤生长在内的雌激素作用。