Ito A, Kawashima K, Fujimoto N, Watanabe H, Naito M
Cancer Res. 1985 Dec;45(12 Pt 1):6436-41.
A new transplantable pituitary tumor, designated MtT/F84, was induced in estrogenized female F344 rats and has been serially passaged in 17 beta-estradiol-treated females. It grew well in rats treated with estrone, 17 beta-estradiol, or estriol but not in intact females or in rats given progesterone or testosterone. The growth of MtT/F84 in rats grafted with up to 1.6 X 10(6) tumor cells and given 17 beta-estradiol was inhibited by orally administered high dose bromocriptine (37.5 mg/kg in food) or by intraperitoneal injection of tamoxifen citrate but was not inhibited by low dose bromocriptine (3.75 mg/kg in food). The tumors grown in intact females contain high amounts of estrogen receptor, and they were greatly reduced in the tumors grown either in 17 beta-estradiol or 17 beta-estradiol-plus-tamoxifen loaded rats. However, administration of bromocriptine resulted in estrogen receptor levels significantly higher than those of tumors grown in 17 beta-estradiol. The existence of dopamine receptor was also confirmed. Growth inhibition of MtT/F84 either by high dose bromocriptine or by tamoxifen may be a direct action and may be an estrogen and dopamine receptor-mediated phenomenon.
一种新的可移植垂体肿瘤，命名为MtT/F84，在雌激素化的雌性F344大鼠中诱发，并已在17β-雌二醇处理的雌性大鼠中连续传代。它在接受雌酮、17β-雌二醇或雌三醇处理的大鼠中生长良好，但在未处理的雌性大鼠或接受孕酮或睾酮处理的大鼠中不生长。在移植了多达1.6×10(6)个肿瘤细胞并给予17β-雌二醇的大鼠中，口服高剂量溴隐亭（食物中37.5毫克/千克）或腹腔注射枸橼酸他莫昔芬可抑制MtT/F84的生长，但低剂量溴隐亭（食物中3.75毫克/千克）则无此作用。在未处理雌性大鼠中生长的肿瘤含有大量雌激素受体，而在17β-雌二醇或17β-雌二醇加枸橼酸他莫昔芬处理的大鼠中生长的肿瘤中雌激素受体含量则大大降低。然而，给予溴隐亭导致雌激素受体水平显著高于在17β-雌二醇中生长的肿瘤。多巴胺受体的存在也得到了证实。高剂量溴隐亭或他莫昔芬对MtT/F84的生长抑制可能是一种直接作用，可能是雌激素和多巴胺受体介导的现象。
