Elgavish A, Meezan E
Department of Pharmacology, University of Alabama, Birmingham Medical School 35294.
Biochem Biophys Res Commun. 1988 Apr 15;152(1):99-106. doi: 10.1016/s0006-291x(88)80685-5.
Sulfate uptake into skin fibroblasts from patients with cystic fibrosis is increased. Sulfate transport studies were carried out in skin fibroblasts isolated from age/sex matched cystic fibrosis and normal subjects. Sulfate transport occurred mainly via a carrier-mediated proton-stimulated S04(2)-/Cl-exchange. The capacity (Vmax) of the uptake system operating at physiological concentrations of sulfate was stimulated in cystic fibrosis, but the affinity of the carrier for sulfate was not altered.
囊性纤维化患者皮肤成纤维细胞对硫酸盐的摄取增加。对从年龄/性别匹配的囊性纤维化患者和正常受试者分离出的皮肤成纤维细胞进行了硫酸盐转运研究。硫酸盐转运主要通过载体介导的质子刺激的SO4(2)-/Cl-交换进行。在生理浓度的硫酸盐条件下，囊性纤维化患者中负责摄取的系统的容量（Vmax）受到刺激，但载体对硫酸盐的亲和力未改变。
