由于异嗜性抗体干扰导致血清雌二醇假性升高：一例报告。
Falsely elevated serum estradiol due to heterophile antibody interference: a case report.
机构信息
Division of Endocrinology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
Arch Endocrinol Metab. 2021 Nov 1;65(2):237-241. doi: 10.20945/2359-3997000000324. Epub 2021 Feb 15.
Abstract
Falsely elevated estradiol is rare, may result from heterophile antibody interference, and can result in unnecessary investigation and intervention. We present the case of a 56-year-old female with falsely elevated estradiol levels inconsistent with her overall clinical picture, which ultimately led to an unnecessary surgical procedure. With the use of alternative analytical platforms and a heterophile antibody blocking agent, we determined the false elevation was due to heterophile antibody interference. Clinicians must suspect and investigate for laboratory error when the clinical picture contradicts laboratory results.
摘要
雌二醇假性升高较为罕见，可能由异嗜性抗体干扰所致，并可能导致不必要的检查和干预。我们报告了 1 例 56 岁女性患者，其雌二醇水平升高与整体临床情况不符，最终导致了不必要的手术。通过使用替代分析平台和异嗜性抗体阻断剂，我们确定了这种假性升高是由于异嗜性抗体干扰所致。当临床表现与实验室结果不符时，临床医生必须怀疑并调查实验室误差。
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