Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu-City, Aichi 474-8511, Japan.
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu-City, Aichi 474-8511, Japan.
Arch Gerontol Geriatr. 2021 May-Jun;94:104376. doi: 10.1016/j.archger.2021.104376. Epub 2021 Feb 9.
Longitudinal studies have shown that mild cognitive impairment (MCI) reverts to normal cognition (NC). However, we could not find any reports on the examination of changes in lifestyle activity patterns in older adults diagnosed with MCI and their outcomes, in a longitudinal study. We determined the changes in lifestyle activity patterns among older adults with MCI.
The participants in this study were 769 community-dwelling older adults aged ≥65 years with MCI at baseline. Four years later, participants were categorized into reverters, maintainers, and converters who reverted from MCI to NC, maintained MCI, and had global cognitive impairment or Alzheimer disease, respectively. We used latent class analysis to classify changes in instrumental activities of daily living, and in cognitive, social, and productive activities of the participants. Subsequently, a multinomial logistic regression analysis was performed with reversion status and class membership as the dependent and independent variables, respectively.
The reversion rate of 769 participants was 33.3%. The reverters maintained multidomain lifestyle activities, converters discontinued multidomain lifestyle activities or were inactive, and maintainers maintained productive activities. According to the logistic regression analysis, the activity patterns of those who continued to engage in multidomain lifestyle activities and start activities, were more likely to help in reverting from MCI to NC (P < 0.05).
Community-dwelling older adults with MCI who continued their multidomain lifestyle activities were more likely to revert to NC. Even if it does not revert to NC, continuing productive activities is important to maintaining MCI without converting.
纵向研究表明，轻度认知障碍（MCI）会恢复为正常认知（NC）。然而，我们在一项纵向研究中未发现任何关于 MCI 老年患者生活方式活动模式变化及其结果的报道。我们确定了 MCI 老年患者生活方式活动模式的变化。
本研究的参与者为 769 名基线时患有 MCI 的 65 岁及以上社区居住的老年人。4 年后，将参与者分为恢复者、维持者和转化者，他们分别从 MCI 恢复为 NC、维持 MCI 以及患有整体认知障碍或阿尔茨海默病。我们使用潜在类别分析来对参与者的工具性日常生活活动、认知、社会和生产活动的变化进行分类。随后，使用多项逻辑回归分析，将恢复状态和类别成员作为因变量和自变量。
769 名参与者的恢复率为 33.3%。恢复者保持了多领域的生活方式活动，转化者停止了多领域的生活方式活动或不活跃，维持者保持了生产活动。根据逻辑回归分析，继续从事多领域生活方式活动和开始活动的人，更有可能从 MCI 恢复为 NC（P<0.05）。
继续进行多领域生活方式活动的 MCI 社区居住老年人更有可能恢复为 NC。即使不能恢复为 NC，继续进行生产活动对于维持 MCI 不转化也很重要。
