Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Curr Opin Immunol. 2021 Apr;69:18-28. doi: 10.1016/j.coi.2021.01.001. Epub 2021 Feb 12.
Cancer immunotherapies are receiving increasing approval in the clinic, but still only a fraction of patients benefit long-term. Understanding the most important mechanisms of immunotherapeutic resistance is critical for broader utility and benefit of cancer immunotherapy. While the tumor microenvironment (TME) is made up of many cell types, immunosuppressive monocytes/macrophages, granulocytes and myeloid derived suppressor cells interact with, and play a critical role in regulating the anti-tumor lymphocyte effector cells that mediate effective immunotherapies. Herein, we discuss the latest research that has identified and compared the importance of pro-tumor and immunosuppressive mechanisms that tumor infiltrating myeloid cells employ. Exploiting this new information may help to develop totally novel therapies to boost contemporary cancer immunotherapy.
癌症免疫疗法在临床上越来越受到认可，但只有少数患者能长期受益。了解免疫治疗耐药的最重要机制对于扩大癌症免疫治疗的应用和获益至关重要。肿瘤微环境（TME）由多种细胞类型组成，免疫抑制性单核细胞/巨噬细胞、粒细胞和髓系来源的抑制细胞与介导有效免疫治疗的抗肿瘤淋巴细胞效应细胞相互作用，并在其中发挥关键作用。在此，我们讨论了最新的研究成果，这些研究确定并比较了肿瘤浸润髓系细胞采用的促肿瘤和免疫抑制机制的重要性。利用这些新信息可能有助于开发全新的疗法来增强当代癌症免疫疗法。
