Cardiology Department, Yeditepe University Hospital, Istanbul, Turkey,
Cardiology Department, Dr. Siyami Ersek Training and Research Hospital, Istanbul, Turkey.
Cardiology. 2021;146(3):288-294. doi: 10.1159/000513144. Epub 2021 Feb 15.
The relationship between heme oxygenase-1 (HO-1) levels and atherosclerosis was investigated in multiple studies. The aim of this study was to establish the relationship between HO-1 levels and coronary SYNergy between percutaneous coronary intervention with TAXus and Cardiac Surgery (SYNTAX) score in patients with stable coronary artery disease (CAD).
Patients who had been planned to undergo invasive coronary angiography due to a suspected CAD, between the dates of September and December 2019, were included in the study. Serum HO-1 levels were measured from peripheral venous blood. The SYNTAX score was calculated using standard coronary angiography images. Regression analysis was performed to establish the relationship between HO-1 levels and the SYNTAX score.
In total, 137 patients were included. The median age was 63 years (IQR: 15), and most of the patients were male (75.2%). The median HO-1 level was 1.44 (IQR: 0.88) ng/mL, and the median SYNTAX score was 6 (IQR: 13). Regression analysis showed that HO-1 is the single most important variable associated with the SYNTAX score (HO-1 levels from 1.01 to 1.87 ng/mL, OR: 6.77, 95% confidence interval 5.18-8.36, p < 0.0001).
In this study, serum HO-1 levels were significantly associated with the coronary SYNTAX score.
多项研究探讨了血红素加氧酶-1（HO-1）水平与动脉粥样硬化的关系。本研究旨在确定稳定型冠状动脉疾病（CAD）患者HO-1水平与冠状动脉 SYNergy 经皮冠状动脉介入治疗与心脏手术（SYNTAX）评分之间的关系。
本研究纳入了 2019 年 9 月至 12 月期间因疑似 CAD 而计划接受有创冠状动脉造影的患者。从外周静脉血中测量血清 HO-1 水平。使用标准冠状动脉造影图像计算 SYNTAX 评分。进行回归分析以确定 HO-1 水平与 SYNTAX 评分之间的关系。
共纳入 137 例患者，中位年龄为 63 岁（IQR：15），大多数患者为男性（75.2%）。中位 HO-1 水平为 1.44（IQR：0.88）ng/mL，中位 SYNTAX 评分为 6（IQR：13）。回归分析表明，HO-1 是与 SYNTAX 评分最密切相关的单一变量（HO-1 水平在 1.01 至 1.87 ng/mL 之间，OR：6.77，95%置信区间 5.18-8.36，p<0.0001）。
本研究表明，血清 HO-1 水平与冠状动脉 SYNTAX 评分显著相关。
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