血清嗜铬粒蛋白 A 水平与冠状动脉疾病的 SYNTAX 评分相关。
Serum chromogranin A levels are associated with the SYNTAX score in coronary artery disease.
机构信息
Tekirdağ Namık Kemal Üniversitesi, Faculty of Medicine, Department of Medical Biochemistry - Tekirdağ, Turkey.
Tekirdağ Namık Kemal Üniversitesi, Faculty of Medicine, Department of Cardiology - Tekirdağ, Turkey.
出版信息
Rev Assoc Med Bras (1992). 2023 Apr 14;69(4):e20221254. doi: 10.1590/1806-9282.20221254. eCollection 2023.
OBJECTIVE
In this article, we investigated the association of chromogranin A with coronary artery disease.
METHODS
Biochemical parameters and chromogranin A levels obtained from peripheral blood samples during coronary angiography were analyzed in 90 patients. Patients were classified into two groups, namely, SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1 (n=45) and SYNergy between PCI with TAXUS and Cardiac Surgery score=0 (n=45). This is a cross-sectional, prospective study.
RESULTS
Serum chromogranin A levels were significantly higher in the group with SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1 compared to the group with SYNergy between PCI with TAXUS and Cardiac Surgery score=0 (1381.5±418.9 ng/mL and 1121.2±290.7 ng/mL, respectively; p=0.002). Serum chromogranin A levels were correlated with SYNergy between PCI with TAXUS and Cardiac Surgery score (r=0.556, p<0.04). ROC analysis showed that the area under the curve for serum chromogranin A levels was 0.687 (p=0.007), and the best cutoff value of 1,131 ng/mL had a sensitivity of 67% and a specificity of 65% for the prediction of coronary artery disease.
CONCLUSION
Serum chromogranin A levels were increased in coronary artery disease patients with SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1. Increasing serum chromogranin A levels are proportional to the SYNergy between PCI with TAXUS and Cardiac Surgery score.
目的
本文旨在探讨嗜铬粒蛋白 A 与冠状动脉疾病的相关性。
方法
对 90 例行冠状动脉造影术患者的外周血样本进行生化参数和嗜铬粒蛋白 A 水平检测，并根据 SYNergy between PCI with TAXUS and Cardiac Surgery 评分将患者分为两组：SYNergy between PCI with TAXUS and Cardiac Surgery 评分≥1 组（n=45）和 SYNergy between PCI with TAXUS and Cardiac Surgery 评分=0 组（n=45）。这是一项横断面前瞻性研究。
结果
SYNergy between PCI with TAXUS and Cardiac Surgery 评分≥1 组患者的血清嗜铬粒蛋白 A 水平明显高于 SYNergy between PCI with TAXUS and Cardiac Surgery 评分=0 组（分别为 1381.5±418.9 ng/mL 和 1121.2±290.7 ng/mL，p=0.002）。血清嗜铬粒蛋白 A 水平与 SYNergy between PCI with TAXUS and Cardiac Surgery 评分呈正相关（r=0.556，p<0.04）。ROC 分析显示，血清嗜铬粒蛋白 A 水平的曲线下面积为 0.687（p=0.007），最佳截断值为 1131ng/mL 时，对冠状动脉疾病的预测具有 67%的敏感性和 65%的特异性。
结论
SYNergy between PCI with TAXUS and Cardiac Surgery 评分≥1 的冠状动脉疾病患者血清嗜铬粒蛋白 A 水平升高，且血清嗜铬粒蛋白 A 水平升高与 SYNergy between PCI with TAXUS and Cardiac Surgery 评分呈正相关。
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