冠心病患者中血红素加氧酶-1与胆红素的血液水平

Blood levels of heme oxygenase-1 versus bilirubin in patients with coronary artery disease.

作者信息

Kishimoto Yoshimi, Niki Hanako, Saita Emi, Ibe Susumu, Umei Tomohiko, Miura Kotaro, Ikegami Yukinori, Ohmori Reiko, Kondo Kazuo, Momiyama Yukihiko

机构信息

Endowed Research Department "Food for Health", Ochanomizu University, Tokyo, Japan.

Department of Cardiology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.

出版信息

Clin Chim Acta. 2020 May;504:30-35. doi: 10.1016/j.cca.2020.01.030. Epub 2020 Jan 30.

DOI:10.1016/j.cca.2020.01.030

PMID:32006543

Abstract

OBJECTIVE

Heme oxygenase-1 (HO-1) degrades heme to CO, iron, and biliverdin/bilirubin. Although serum bilirubin levels were often reported in patients with coronary artery disease (CAD), HO-1 levels in patients with CAD and the association between HO-1 and bilirubin levels have not been clarified.

METHODS

We measured plasma HO-1 and serum total bilirubin levels in 262 patients undergoing coronary angiography.

RESULTS

HO-1 levels were higher in patients with CAD than without CAD (median 0.46 vs. 0.35 ng/mL, P < 0.01), but bilirubin were lower in patients with CAD than without CAD (0.69 vs. 0.75 mg/dL, P < 0.02). Notably, HO-1 levels in CAD(-), 1-vessel, 2-vessel, and 3-vessel disease were 0.35, 0.51, 0.45, and 0.44 ng/mL, and were highest in 1-vessel disease (P < 0.05). Bilirubin levels in CAD(-), 1-vessel, 2-vessel, and 3-vessel disease were 0.75, 0.70, 0.68, and 0.66 mg/dL (P = NS). No correlation was found between HO-1 and bilirubin levels. In multivariate analysis, HO-1 levels were a significant factor for CAD independent of atherosclerotic risk factors and bilirulin levels. Odds ratio for CAD was 2.32 (95%CI = 1.29-4.17) for high HO-1 (>0.35 ng/mL).

CONCLUSIONS

Patients with CAD were found to have high HO-1 and low bilirubin levels in blood, but no correlation was found between HO-1 and bilirubin levels.

摘要

目的

血红素加氧酶-1（HO-1）可将血红素降解为一氧化碳、铁和胆绿素/胆红素。虽然冠状动脉疾病（CAD）患者的血清胆红素水平常有报道，但CAD患者的HO-1水平以及HO-1与胆红素水平之间的关联尚未明确。

方法

我们检测了262例接受冠状动脉造影患者的血浆HO-1和血清总胆红素水平。

结果

CAD患者的HO-1水平高于非CAD患者（中位数0.46对0.35 ng/mL，P<0.01），但CAD患者的胆红素水平低于非CAD患者（0.69对0.75 mg/dL，P<0.02）。值得注意的是，CAD（-）、单支血管病变、双支血管病变和三支血管病变患者的HO-1水平分别为0.35、0.51、0.45和0.44 ng/mL，单支血管病变患者的HO-1水平最高（P<0.05）。CAD（-）、单支血管病变、双支血管病变和三支血管病变患者的胆红素水平分别为0.75、0.70、0.68和0.66 mg/dL（P=无显著性差异）。未发现HO-1与胆红素水平之间存在相关性。在多变量分析中，HO-1水平是CAD的一个独立于动脉粥样硬化危险因素和胆红素水平的显著因素。HO-1水平高（>0.35 ng/mL）的CAD患者的比值比为2.32（95%可信区间=1.29-4.17）。