蹒跚突变小鼠的自发交替与探索行为

Spontaneous alternation and exploration in staggerer mutant mice.

作者信息

Lalonde R, Manseau M, Botez M I

机构信息

Service of Neurology, Hôtel-Dieu Hospital, University of Montreal, Canada.

出版信息

Behav Brain Res. 1988 Mar;27(3):273-6. doi: 10.1016/0166-4328(88)90124-6.

DOI:10.1016/0166-4328(88)90124-6

PMID:3358865

Abstract

Staggerer mutant mice were found to be less active in terms of motor activity in a maze, hole poking and rearing. Staggerer mutant mice also showed a lack of spontaneous alternation in both 2-trial and 4-trial tests. A lack of spontaneous alternation in this mutant may be due to a deficit in response inhibition or in spatial orientation, similar to that of animals with limbic lesions.

摘要

摇 staggerer 突变小鼠在迷宫中的运动活动、探洞和竖毛方面表现出较低的活跃度。摇 staggerer 突变小鼠在两次试验和四次试验测试中也均表现出缺乏自发交替行为。该突变体缺乏自发交替行为可能是由于反应抑制或空间定向缺陷，类似于边缘系统损伤的动物。