Bondesen S, Schou J B, Pedersen V, Rafiolsadat Z, Hansen S H, Hvidberg E F
Department of Internal Medicine, Elsinore Hospital, Denmark.
Br J Clin Pharmacol. 1988 Feb;25(2):269-72. doi: 10.1111/j.1365-2125.1988.tb03301.x.
In order to clarify the characteristics of absorption of 5-aminosalicylic acid (5-ASA) from the colon, a neutral solution was instilled into the right part of the colon and the rectum, respectively, in six volunteers. A laxative (bisacodyl) and liquid meals were given prior to each instillation. No significant difference could be demonstrated between the two parts of the large bowel, but the absorption was considerably restricted compared with previous results obtained from the jejunum. The results confirm in a direct manner earlier observations on 5-ASA released from sulphasalazine.
为了阐明5-氨基水杨酸（5-ASA）在结肠的吸收特性，分别向6名志愿者的结肠右侧和直肠内注入中性溶液。每次注入前均给予泻药（比沙可啶）和流食。大肠的这两个部位之间未显示出显著差异，但与先前从空肠获得的结果相比，吸收受到了相当大的限制。这些结果直接证实了早期对柳氮磺胺吡啶释放的5-ASA的观察结果。
