Department of Pediatrics, Division of Newborn Medicine, Washington University, St. Louis, MO, USA.
Department of Pediatrics, Division of Newborn Medicine, Mountainside Medical Center, Montclair, NJ, USA.
J Perinatol. 2021 Apr;41(4):675-688. doi: 10.1038/s41372-021-00946-6. Epub 2021 Feb 15.
Brain injury is one of the most consequential problems facing neonates, with many preterm and term infants at risk for cerebral hypoxia and ischemia. To develop effective neuroprotective strategies, the mechanistic basis for brain injury must be understood. The fragile state of neonates presents unique research challenges; invasive measures of cerebral blood flow and oxygenation assessment exceed tolerable risk profiles. Near-infrared spectroscopy (NIRS) can safely and non-invasively estimate cerebral oxygenation, a correlate of cerebral perfusion, offering insight into brain injury-related mechanisms. Unfortunately, lack of standardization in device application, recording methods, and error/artifact correction have left the field fractured. In this article, we provide a framework for neonatal NIRS research. Our goal is to provide a rational basis for NIRS data capture and processing that may result in better comparability between studies. It is also intended to serve as a primer for new NIRS researchers and assist with investigation initiation.
脑损伤是新生儿面临的最严重问题之一，许多早产儿和足月儿都有脑缺氧和缺血的风险。为了制定有效的神经保护策略，必须了解脑损伤的机制基础。新生儿的脆弱状态带来了独特的研究挑战；侵入性的脑血流和氧合评估措施超出了可耐受的风险范围。近红外光谱 (NIRS) 可安全、无创地估计脑氧合，这是脑灌注的相关指标，可深入了解与脑损伤相关的机制。不幸的是，设备应用、记录方法和误差/伪影校正缺乏标准化，使得该领域支离破碎。在本文中，我们为新生儿 NIRS 研究提供了一个框架。我们的目标是为 NIRS 数据采集和处理提供合理的依据，从而可能提高研究之间的可比性。它也旨在为新的 NIRS 研究人员提供帮助，并协助研究的启动。
