早产儿早期脑氧合与神经发育损伤或死亡的关系。
Association between early cerebral oxygenation and neurodevelopmental impairment or death in premature infants.
机构信息
Neonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA, USA.
出版信息
J Perinatol. 2021 Apr;41(4):743-748. doi: 10.1038/s41372-021-00942-w. Epub 2021 Feb 15.
OBJECTIVE
To assess the relationship between cerebral oxygenation in the first 72 h of life and neurodevelopmental impairment (NDI) at 2 years corrected age in former premature infants.
STUDY DESIGN
Prospective observational cohort study of 127 infants <32 weeks GA at birth with cerebral oxygenation monitoring using NIRS in the first 72 h of life.
RESULTS
Using a threshold cutoff for cerebral hypoxia, infants with NDI or death had increased duration of hypoxia (4 vs 2.3%, p = 0.001), which was more pronounced in the 23-27 week subgroup (7.6 vs 3.2%, p < 0.001). Individual generalized estimating equations to adjust for repeated measures were modeled in this subgroup for the physiologic parameters including StO. StO < 67% was a predictor for death or NDI (OR 2.75, 95% CI 1.006, 7.5132, p = 0.049).
CONCLUSION
An increased duration of cerebral hypoxia is associated with NDI or death in infants born <32 weeks GA.
目的
评估生命最初 72 小时内的脑氧合与校正年龄 2 岁时神经发育障碍（NDI）之间的关系。
研究设计
对 127 名出生时胎龄<32 周的早产儿进行前瞻性观察队列研究，在生命最初 72 小时内使用近红外光谱（NIRS）监测脑氧合。
结果
使用脑缺氧的阈值截定点，患有 NDI 或死亡的婴儿缺氧持续时间更长（4% vs 2.3%，p=0.001），在 23-27 周亚组中更为明显（7.6% vs 3.2%，p<0.001）。对该亚组的生理参数（包括 StO）进行了个体广义估计方程以进行重复测量校正。StO<67%是死亡或 NDI 的预测因子（OR 2.75，95% CI 1.006，7.5132，p=0.049）。
结论
出生胎龄<32 周的婴儿脑缺氧持续时间延长与 NDI 或死亡相关。
Zotero 插件