Tsafriri A, Picard J Y, Josso N
Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.
Biol Reprod. 1988 Mar;38(2):481-5. doi: 10.1095/biolreprod38.2.481.
The ability of immunopurified, biologically potent anti-Müllerian hormone (AMH) to inhibit the spontaneous resumption of meiosis of rat oocytes was tested in vitro. Two different batches of AMH in the range of 0.75-9.0 micrograms/protein did not suppress the spontaneous resumption of meiosis. Neither did AMH (6 micrograms/ml) induce meiotic resumption of follicle-enclosed oocytes in culture. It is concluded, therefore, that AMH has no oocyte meiosis-inhibiting activity.
在体外测试了免疫纯化的、具有生物活性的抗苗勒管激素（AMH）抑制大鼠卵母细胞减数分裂自发恢复的能力。两批不同的AMH，浓度范围为0.75 - 9.0微克/蛋白质，均未抑制减数分裂的自发恢复。AMH（6微克/毫升）也未诱导培养中卵泡包裹的卵母细胞发生减数分裂恢复。因此得出结论，AMH没有抑制卵母细胞减数分裂的活性。
